Eudistoma glaucus

KobayashiJ, NakamuraH, Ohizumi Y, HirataY, Eudistomidin-A, anovelcalmodulin antagonist from the Okinawan tunicate Eudistoma glaucus, Tetrahedron Lett 27 1191-1194, 1986. 

Kobayashi J, Cheng JF, Ohta T Nozoe S, Ohizumi Y, Sasaki T, Eudistomidins B, C, and D Novel antileukemic alkaloids from the Okinawan marine tunicate Eudistoma glaucus, J Org Chem 55 3666—3670, 1990. 

Eudistomidin C (90) was one of three antileukaemic (3-carboline alkaloids isolated from an Okinawan sample of Eudistoma glaucus. It was identified by spectral methods and synthesis of a derivative [114]. Eudistomidins E (91) and F (92) were isolated from E. glaucus from Okinawa and identified by spectroscopic techniques [115]. 

Marine tunicates are a rich source of intriguing structures and interesting biological activities. Eudistomidin A (1) from the Okinawan tunicate Eudistoma glaucus possesses powerful calmodulin antagonistic activity (IC5o 3 x 10 M). Eudistomidins B-D (2-4) show potent cytotoxicity... 

The P-carboline alkaloid eudistomidins were isolated from the Okinawan tunicate Eudistoma glaucus. A methyl sulfide group is present in eudistomidins C (27) [30] and E (28) [32] while a methyl sulfoxide occurs in eudistomidin F (29) [32]. Their structures were elucidated on the basis of spectroscopic data. The 5 configuration at C-10 of eudistomidin C (27) was established by synthesis of 10-(/ )-Omethyleudistomidin C [30]. The... 

P-Carbolines which have other substituents at Cl include eudistomin U (142) from the Caribbean didemnid Lissoclinum fragile [95], eudistomidins C (143) [96,97], E (144) [98] and F (145) [98] from the Okinawan ascidian Eudistoma glaucus, eudistomins R (146), S (147) and T (148) from the... 

Suzuki T, KubotaT, Kobayashi J. Eudistomidins H - K, new beta-carboline alkaloids from the Okinawan marine tunicate Eudistoma glaucus. Bioorg Med Chem Lett 2011 21(14) 4220-3. 

Takahashi Y, Ishiyama H, Kubota T, Kobayashi J. Eudistomidin G, a new beta-carboUne alkaloid from the Okinavan marine tunicate Eudistoma glaucus and structure revision of eudistomidin B. Bioorg Med Chem 2010 20(14) 4100-3. 

Murata, 0., Shigemori, H., Ishibashi, M., Sugama, K., Hayashi, K., Kobayashi, J., (1991). Eudistomidins E and F, new p-carboline alkaloids from the Okinawan marine tanicate Eudistoma glaucus. Tetrahedron Lett. 32,3539-3542. 

Takahashi, Y., Ishiyama, H., Kubota, T., Kobayashi, J., (2010). Eudistomidin G, a new P-earboline alkaloid from the Okinawan marine tunieate Eudistoma glaucus and strueture revision of eudistomidin B. Bioorg. Med. Chem. Lett. 20, 4100-4103. 

Eudistomins B-D. A group of three carbazole alkaloids were isolated from the Okinawan marine tunicate, Eudistoma glaucus, and their structures... 

Kobayashi J, Murayama T, Ohizumi Y, Sasaki T, Ohta T, Nozoe S (1989) Theonelladins A-D, novel antineoplastic pyridine alkaloids from the Okinawan marine sponge Theonella swinhoei. Tetrahedron Lett 30 4833-4836 Kobayashi J, Cheng J-f, Ohta T, Nozoe S, Ohizumi Y, Sasaki T (1990a) Eudistomidins B, C and D novel antileukemic alkaloids from the Okinawan marine tunicate Eudistoma glaucus. J Org, Chem 55 3666-3670... 

Several P-carboHne alkaloids related to eudistomins were isolated from Eudistoma glaucus and other species of Eudistoma, such as E. album, E.fragum, and E. gUboverde. Generally, these derivatives have antiviral and antitumor activities similar to those of eudistomins, but eudistomi-din A is also an antagonist of calmodulin (Kobayashi, Nakamura, and Ohizumi, 1986). Some members of this series are presented in Figure 28.21. 

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