Calibration, of equipment

Identify the critical parts of the analytical process. These will have to be controlled by careful operation and calibration. Cross-reference to the relevant sections above. Include calibration of equipment - what needs to be calibrated, how, with what and how often Consider the appropriate traceability of calibrants and highlight any limitations associated with available calibrants. 

Maintenance and calibration of equipment Standard operating procedures... 

The programmes for calibration of equipment shall be designed and operated in a way to ensure that calibrations and measurements made by the calibration laboratory are traceable to the International System of Units (SI) (Systeme international d unites). 

Reliability Competence of personnel Suitability of equipment Calibration of equipment Interlaboratory comparisons Method validation... 

Check the Code of Federal Regulations, Chapter 40, Part 160.81, and tell whether an SOP is required for maintenance and calibration of equipment. 

Calibration of equipment This is a routine requirement, and the FDA inspectors may not review these data if they find that the firm is in general good compliance with the cGMP. However, these data should be updated and current at all times. 

Third, using properly maintained and calibrated equipment. There is nothing particularly new about this. We expect to see records of calibration of equipment, either done as a separate routine or as part of the analytical sequence. Moreover, we expect to see a written record of these calibrations and the record should be unique to that piece of equipment. The equipment should be properly maintained and there is to be a record of this maintenance. You maintain and service it, the dealer does it, the factory does it, whatever. Someplace there is a log that shows when the equipment was taken out of service, what was wrong, when it was fixed and recalibrated, and when it was put back into service. Why - because the... 

Review maintenance and calibration of equipment, placing special emphasis on QC acceptance criteria. This can be accomplished... 

Note Procedural controls for computer applications may include development, use, and support of systems, data handling, storage and retrieval, maintenance, repair, calibration of equipment, management and personnel responsibilities, record retention, training. 

The equipment will be brought by the IT or by cargo to the OPCW equipment store. The contents of the transport cases will be checked by the equipment store personnel in the presence of an IT member. The IT will provide detailed reports about equipment left on site as well as malfunction or damage of equipment, if applicable. Necessary repair, maintenance, or calibration of equipment is performed or initiated by the OPCW Technical Support Branch. 

The installation site must be prepared (commissioned) as reqnired and necessary calibration of equipment and instruments conducted. This activity is usually separated from Installation Qnalification. 

The reference sample method is designed to evaluate analytical method, level of calibration of equipment and instruments as well as calculations which are employed by such laboratories. 

PRELIMINARY PROCEDURE INITIAL PREPARATION AND CALIBRATION OF EQUIPMENT... 

A scope for the reference standards covered by the procedure has been defined. For instance, reference standards used for the calibration of equipment may specifically be excluded from the SOP. 

Some systematic instrument errors can be found and corrected by calibration. Periodic calibration of equipment is always desirable because the response of most instruments changes with time as a result of wear, corrosion, or mistreatment. Many systematic instrument errors involve interferences in which a species present in the sample affects the response of the analyte. Simple calibration does not compensate for these effects. Instead, the methods described in Section 8C-3 can be used when such interference effects exist. 

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