Calcium phosphate nanoparticles

Altinoglu El, Russin TJ, Kaiser JM, Barth BM, Eklund PC, Kester M, Adair JH (2008) Near-infrared emitting fluorophore-doped calcium phosphate nanoparticles for in vivo imaging of human breast cancer. ACS Nano 2 2075-2084... 

S. Loher, W.J. Stark, M. Maciejewski, A. Baiker, S.E. Pratsinis, D. Reichardt, F. Maspero, F. Krumeich, D. Gunther, Fluoro-apatite and calcium phosphate nanoparticles by flame synthesis, Chem. Mater. 17 (2005) 36-42. 

Welzel T, Meyer-Zaika W, Epple M (2004) Continuous preparation of functionalised calcium phosphate nanoparticles with adjustable crystallinity. Chem Commun 10 1204-1205... 

Kakizawa Y, Furukawa S, Kataoka K (2004). Block copolymer-coated calcium phosphate nanoparticles sensing intracellular environment for oligodeoxynucleotide and siRNA delivery./. Control. Rel. 97(2) 345-356. 

Various other methods, such as DNA electrotransfer, electroporation-based gene transfer, calcium phosphate nanoparticles, peptide nucleic acids, and cell penetrating peptides, round off the currently used methods in the field of nonviral gene delivery techniques. 

Maitra A (2005). Calcium phosphate nanoparticles Second-generation nonviral vectors in gene therapy. Exp. Rev. Molec. Diagnos. 5 893-905. 

Calcium phosphate nanoparticles are also novel nonviral vectors for gene delivery [58]. Many studies have demonstrated that nanometer calcium phosphates possess higher penetration rates into cell membrane and their transfection efficiency can be up to 25-fold higher than that of conventional particles. Recently, dye-loaded calcium phosphate nanoparticles have been developed for photodynamic therapy against bacteria and cells. The strategy of photodynamic therapy utilizes biocompatible light-sensitive substances (i.e., photosensitizers) that become toxic when exposed to... 

Specific lights to target and destroy malignant or diseased cells. Calcium phosphate nanoparticles have been studied as efficient carriers for the incorporation and delivery of photosensitizers (such as 5,10,15,20-tetrakis(3-hydroxyphenyl)-porphyrin) against cells (e.g synoviocyte, macrophage) and bacteria (e.g., S. aureus) [59,60]. 

However, there is both research and clinical evidence showing nanometer particles released from calcium phosphates may largely impair the abihty of BMSCs to proliferate and mature into a functional osteoblast phenotype [64]. This opposite evidence indicates that more and thorough research on utilizing stem cell and calcium phosphate nanoparticle for bone repair and regeneration is required before possible clinical applications. 

Cai Y, Tang R. Calcium phosphate nanoparticles in hiomineralization and hiomaterials. J Mater Chem 2008 18 3775-87. 

Schwiertz J, Wiehe A, Grafe S, Gitter B, Epple M. Calcium phosphate nanoparticles as efficient carriers for photodynamic therapy against cells and hacteria. Biomaterials 2009 30 3324-31. 

Hu Q, Tan Z, Liu Y, Tao J, Cai Y, Zhang M, et al. Effect of crystallinity of calcium phosphate nanoparticles on adhesion, proliferation, and differentiation of hone marrow mesenchymal stem cells. J Mater Chem 2007 17 4690-8. 

Recent reports [14,72] describe the preparation of various calcium phosphate nanoparticles. It is believed that such products might prove to be of great value in biomedicine, for drug delivery, gene silencing, and so on. Phosphoras-based dendrimers have recently been investigated with a view to medical applications, or as potentially useful nanoparticle or nanotube materials [73,74,75],... 

I. Roy, S. Mitra, A. Maitra and S. Mozumdar, Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery. Int.. Pharm., 250, 25-33 (2003). 

S. Bisht, G. Bhakta, S. Mitra and A. Maitra, pDNA loaded calcium phosphate nanoparticles Highly efficient non-viral vector for gene delivery. Int.. Fhurm., 288,157-168 (2005). 

T. Liu, A. Tang, G. Zhang, Y. Chen, J. Zhang, S. Peng and Z. Cai, Calcium phosphate nanoparticles as a novel nonviral vector for efficient transfection of DNA in cancer gene therapy. Cancer Bio-ther. Radiopharm. 20,141-149 (2005). 

D. Chattopadhyaya, S. Mitra and A. Maitra, Calcium phosphate nanoparticles a non-viral vectors for gene therapy of experimental autoimmune hepatitis. Proceedings of the 31st Annual Meeting and Exposition of the Controlled Release Society, Abstract, 235(2004). 

S. Bisht, D. Chattopadhyay and A. Maitra, Intraperitoneal Administration of Calcium Phosphate Nanoparticles Encapsulating pSVbgal Elicits Immune Response to Encoded Protein, J. Biomed. Nanotechnology, 2,1-10 (2006). 

Figure 1. TEM image of the calcium phosphate nanoparticles (PEO CaCI, (a) 2 1, (b) 4 1, (c) 5 1). Preparation of Nanocomposite Polymer Electrolytes...

DNase, a well characterized and biologically specific enzyme with therapeutic value in the treatment of cystic fibrosis, was chosen as a model agent for studying the effects on an enzymatic bio/molecule of surface immobilization on nanocrystalline ceramic particulates. As the data show, and consistent with previous observations, DNase exhibits a marked retention of biological activity when surface immobilized on the solid phase of a colloid comprised of polyhydroxyl oligomeric films investing degradable calcium-phosphate nanoparticles. 

DNase I was passively adsorbed over 24 hours, 4°C, in situ to calcium phosphate nanoparticles that had been modified with a lyophilized film of adulterated... 

Y. Liu, Y. Hu, and L. Huang, Influence of polyethylene glycol density and surface lipid on pharmacokinetics and biodistribution of lipid-calcium-phosphate nanoparticles. Biomaterials, 35 (9), 3027-3034, 2014. 

Pedraza, C. E., Bassett, D. C., McKee, M. D. et al. 2008. The importance of particle size and DNA condensation salt for calcium phosphate nanoparticle transfection. Biomaterials 29 3384-92. 

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