Calcium-DTPA

Pentetate Calcium Trisodium ([calcium DTPA] and Pentetate Zinc Trisodium [zinc DTPA])... 

SYNS Ba2797 CALCIUMCHED330 CALCIUM-DTPA CALCIUM TRISODIUM CHEL 330 CALCIUM TRISODIUM DTPA CALCIUM TRISODIUM PENTETATE CALCIUM TRISODIUM SALT of DIETHYLENETRLUVONEPENTAACETIC ACID DIETHYLENETRIAMINE PENTAACETIC ACID, CALCIUM TRISODIUM SALT DITRIPENTAT DTPA CALCIUM TRISODIUM SALT PENTACIN PENTACINE PENTETATE TRISODIUM CALCIUM PENTHAMIL... 

CALCIUM DISTEARATE see CAX350 CALCIUM DITHIOCYANATE see CAY250 CALCIUM DITHIONITE (DOT) see CANOOO CALCIUM-DTPA see CAY500 CALCIUM FLUORIDE see CASOOO CALCIUM FLUOROSILICATE see CAX250 CALCIUM FLUOSIUCATE see CAX250 CALCIUM FORMATE see CAS250... 

Synonyms Calcium diethylene triamine pentaacetic acid Calcium DTPA Calcium pentetate Calcium trisodium diethylene triamine pentaacetate Diethylenetriamine pentaacetic acid, calcium trisodium salt Pentetate calcium trisodium Pentetate trisodium calcium Trisodium [(carboxymethyl) imino] bis (ethylenenitrilo) tetraacetate Empihcal CuHisCaNsNasOio Formula CaNasCuHisNaOio Properties Solid sol. in water insol. in alcohol m.w. 497.36... 

Plutonium and other transuranics Chelation with Zinc or Calcium-DTPA... 

Alkaline-earth metals are often deterruined volumetricaHy by complexometric titration at pH 10, using Eriochrome Black T as indicator. The most suitable complexing titrant for barium ion is a solution of diethylenetriaminepentaacetic acid (DTPA). Other alkaline earths, if present, are simultaneously titrated, and in the favored analytical procedure calcium and strontium are deterruined separately by atomic absorption spectrophotometry, and their values subtracted from the total to obtain the barium value. 

Calcium or zinc complexes of polycarboxylate compounds such as DTPA or ethylenediaminetetratacetic acid (EDTA) have been used as chelating agents to accelerate the urinary excretion of americium in humans who were accidentally exposed to americium (Breitenstein 1983 Doerfel and Oliveira 1989 ... 

DTPA extractant - dissolve 3.933 g DTPA in a mixture of 29.844 g TEA (triethanolamine) and 22.22 ml water stir until dissolved. Add 2.944 g calcium chloride (CaCl2.2H20) to 1.1 I of water, and when dissolved, add to the DTPA/TEA solution and make up to about 1.9 I with water. Adjust the pH to 7.3 using hydrochloric acid (approximately 36% m/m HCI) and make up to 2 I. 

The longer the half-life of a metal in a particular organ, the less effectively it will be removed by chelation. For example, in the case of lead chelation with calcium EDTA or succimer, or of plutonium chelation with DTPA, the metal is more effectively removed from soft tissues than from bone, where incorporation into bone matrix results in prolonged retention. 

EDTA, DTPA, DTPMP, and EDTM Pare all strong chelants across all metals, which is why they are so widely used. Phosphonates can also prevent scale formation by inhibiting the crystal growth of calcium carbonate, of which none of the amino-carboxylates and polysuccinates are capable. This strength can also be a weakness, in that they can be less selective for transition metal ions in the presence of hardness... 

In this procedure the pentameglumine salt of the ligand DTPA was added to prevent any undesired release of the gadolinium ion from the chelate. Gadolinium-complex formulations normally contain a small amount of excess ligand either in its free or calcium-complexed form. As mentioned above, Pro-Hance (gadoteridol) contains calteridol, the calcium salt of the relatively weak calcium complex of the ligand for instance. 

Because the drug and the mobilized metals are excreted via the urine, the drug is contraindicated in anuric patients. Nephrotoxicity from EDTA has been reported, but in most cases this can be prevented by maintenance of adequate urine flow, avoidance of excessive doses, and limitation of a treatment course to 5 or fewer consecutive days. EDTA may result in temporary zinc depletion that is of uncertain clinical significance. An experimental analog of EDTA, calcium disodium diethylenetriaminepentaacetic acid (DTPA), has been used for removal ("decorporation") of uranium, plutonium, and other heavy radioisotopes from the body. 

As seen in Table 2.10, the stability constants of the tartarate and citrate complexes of lead and calcium ions are much smaller than those of EDTA and DTPA complexes. The calculations show that the dominant species of cations are Pb2+ and Ca2+ at pH < 4, and so the same ion exchange can be expected as would happen without complex-forming agents. At pH > 4, the effect of citric acid is significantly higher than expected from stability constants. The structure of citrate... 

Nagy, N. M., J. Kdnya, and I. Kdnya. 1998b. Ion exchange processes of lead and cobalt ions on the surface of calcium-montmorillonite in the presence of complex forming agents. II. The effect of DTPA, tartaric acid and citric acid on the sorption of lead ion on calcium-montmorillonite. Coll. Surf. 137 243-252. 

Following exposure to plutonium, curium and americium, chelation with pentate calcium trisodium (CaDTPA), pentate zinc trisodium (Zn-DTPA), or dimercapto-propane-1-sulfonic acid (DMPS) can be administered (Chung Shannon, 2005). Ca-DTPA and Zn-DTPA chelate with metals and are excreted in the urine (Chung Shannon, 2005). These medications are administered by inhalation or intravenous routes at a dosage of 14 mg/kg IV, up to a maximum of 1 g (Chung Shannon, 2005). 

CALCIUM TRISODIUM DIETHYLENE TRIAMINE PENTAACETATE see CAY500 CALCIUM TRISODIUM DTPA see CAY500 CALCIUM TRISODIUM PENTETATE see CAY500 CALCIUM TRISODIUM SALT of DIETHYLENETRIAMINEPENTAACETIC ACID see CAY500... 

Minimum % Active Agent 30% DTPA as calcium-sodium salt... 

Another hepatocyte-specific contrast formulation, dysprosium ethoxybenzyltris(carboxylatomethyl)triazaun-decanedioic acid diethylenetriaminepenta-acetic acid (Dy-EOB-DTPA), has been used for Uver CT imaging (266). It contains calcium-EOB-DTPA (0.5 mg/ml), tro-metamol (1.2 mg/ml), and hydrochloric acid (final pH 7.4). It has been described as a stable metal chelate with high tolerability in vitro and in animal studies, in which a long-lasting increase in CT density of about 30 Hounsfield units has been reported. A total of 40 healthy male volunteers (mean age 33 years) received intravenous infusions... 

Clinical management can potentially reduce the effects of plutonium intake, although the effectiveness can be highly variable. Administration of the calcium salt of diethylenetriaminepentaacetic acid (DTPA) can accelerate removal of soluble forms of plutonium from body fluids and recent deposits. It is unable to remove intracellular deposits or activity buried in bone and must therefore be administered as soon as possible after an intake. In a review of 18 patients exposed to plutonium, americium, or curium, the US Food and Drug Administration concluded that administration of 1 g Ca-DTPA in 5 ml sterile aqueous solution, either by intravenous injection or as a nebulized inhalation dose, increased the rate of radioactivity elimination in urine by an average of 39-fold. Daily maintenance doses of Zn-DTPA resulted in continued elimination of radioactivity. 

For treatment when acute nephrotoxicity is possible, alkalinization of the urine is important to increase urinary excretion of uranium. Systemic chelating agents, such as calcium or zinc salts of diethylenetria-minepentaacetic acid (Ca-DTPA or Zn-DTPA), although recommended in some publications, have not been shown to be useful in increasing the excretion of uranium. 

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