Buxus sempervirens

The path from squalene (114) to the corresponding oxide and thence to lanosterol [79-63-0] (126), C qH qO, cholesterol [57-88-5] (127), and cycloartenol [469-38-5] (128) (Fig. 6) has been demonstrated in nonphotosynthetic organisms. It has not yet been demonstrated that there is an obligatory path paralleling the one known for generation of plant sterols despite the obvious stmctural relationships of, for example, cycloartenol (128), C qH qO, to cyclobuxine-D (129), C25H42N2O. The latter, obtained from the leaves of Buxus sempervirens E., has apparentiy found use medicinally for many disorders, from skin and venereal diseases to treatment of malaria and tuberculosis. In addition to cyclobuxine-D [2241-90-9] (129) from the Buxaceae, steroidal alkaloids are also found in the Solanaceae, Apocynaceae, and LiUaceae. 

ATA A, NAZ s, CHOUDHARY M I, ATTA-UR-RAHMAN, SENER B, TURKOZ s (2002) New triterpenoidal alkaloids from Buxus sempervirens. Z Naturforsch [C]. 57 21-8. 

N.A. Buxus sempervirens L. Steroidal alkaloids, alpha-tocopherol. 125,275 Used for recurrent fevers, rheumatism, intestinal parasites. 

Tominaga, T. and D. Dubourdieu. 1997. Identification of 4-mercapto-4-methylpentan-2-one from the box tree (Buxus sempervirens L.) and broom (Sarothamnus scoparius (L.) Koch.). Flavour and Fragrance J. 12 373-376. 

Alpinia galanga, Coriandrum sativum, Juniperus rigida, Perilla frutescens, Pinus sylvestris, P. albicaulis, P. contorta, P. mugo, P. palustris, P. strobus, Pistacia lentiscus Impatiens pallida, I. capensis Melaleuca leucadendra Eclipta alba, E. prostrata Biota orientalis Buxus sempervirens Rubia tinctorum Swertia chirata... 

An alkaloid originally isolated from Buxus sempervirens, and designated /-cycloprotobuxine C,4 has been assigned the unusual (20R) structure (6),5 following mass... 

Two new alkaloids, cyclobuxophylline-O (Id) and buxithienine-M (3), have been isolated from leaves of Buxus sempervirens var. rotundifolia. Also isolated were the known alkaloids buxamine-E, buxaminol-B, buxpiine-K, buxtauine-M, cyclo-bullatine-A, cyclobuxine-D, cycloprotobuxine-C, and cyclovirobuxine-D (4),... 

Buxozine-C (22) was isolated from Buxus sempervirens It is the first buxus alkaloid having a tetrahydrooxazine heterocycle fused in positions 16 , lip of the steroid backbone. 

Noteworthy is the isolation of irehine, initially named buxomegine, from the leaves of Buxus sempervirens (51, 52). This finding is of interest from the biogenetic point of view since this is the only case where a simple pregnane derivative was found among Buxus alkaloids. 

Key to letters a. Buxus balearica WiWd. b. Buxusmalayana RidX. c. Buxus microphylla Sieb. etZucc. vox. sujfruticosa Makino d. Buxus rolfei Vidal e. Buxus sempervirens L. 

Cycloprotobuxine-C was first isolated from Buxus sempervirens by Schlittler and co-workers (180-183) and was designated alkaloid L. It was later found in other Buxus species (15, 199-201). 

Buxus sempervirens L. (Buxaceae)[also called Buxus wallichiana Baill. (Buxaceae)][176] Buxus wallichiana Baill. (Buxaceae)[also called Buxus sempervirens L. 

Buxenine-G, a cytotoxic alkaloid isolated from Buxus sempervirens, was shown to possess structure XI, which was established unambiguously by x-ray analysis of Buxenine-G dihydroiodide. 

Buxus malayana, - Buxus rolfei, Buxus sempervirens, and Buxus koreana. With few exceptions, these alkaloids have an unusual skeleton containing a cyclopropane ring and are derived from the, 1406-trimethyl-9P, 19-cyclo-5c --pregnane systan. 

Cyclobuxine B has been isolated from the leaves of Buxus sempervirens from the acetone-insoluble portion of the strong bases and, after chemical and spectral analysis, has been assigned structure (31).24... 

Buxazine (C28H48N2O2 mp 238-239° [aj 4-93°) was isolated from Buxus sempervirens 101). Characteristic bands in the IR spectrum... 

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