Butyl Hydrochlorid

TERMINALIA ARJUNA, BARK EXTRACT 5H-TETRAZOLOAZEPINE, 6.7.8.9-TETRAHYDRO-THEOPHYLLINE, 8-PENTYL-THEOPHYLLINE, 7 (1,3 DIOXOLAN-2-YLMETHYL) -THEOPHYLLINE, 8-BUTYL-, HYDROCHLORIDE... 

Therapeutic Function Analeptic, Stimulant, Antidepressant Chemical Name Pyrrolidine, l-(l-(phenylmethyl)butyl)-, hydrochloride Common Name Prolintane hydrochloride Promotil... 

Separations based upon differences in the chemical properties of the components. Thus a mixture of toluene and anihne may be separated by extraction with dilute hydrochloric acid the aniline passes into the aqueous layer in the form of the salt, anihne hydrochloride, and may be recovered by neutralisation. Similarly, a mixture of phenol and toluene may be separated by treatment with dilute sodium hydroxide. The above examples are, of comse, simple apphcations of the fact that the various components fah into different solubihty groups (compare Section XI,5). Another example is the separation of a mixture of di-n-butyl ether and chlorobenzene concentrated sulphuric acid dissolves only the w-butyl other and it may be recovered from solution by dilution with water. With some classes of compounds, e.g., unsaturated compounds, concentrated sulphuric acid leads to polymerisation, sulphona-tion, etc., so that the original component cannot be recovered unchanged this solvent, therefore, possesses hmited apphcation. Phenols may be separated from acids (for example, o-cresol from benzoic acid) by a dilute solution of sodium bicarbonate the weakly acidic phenols (and also enols) are not converted into salts by this reagent and may be removed by ether extraction or by other means the acids pass into solution as the sodium salts and may be recovered after acidification. Aldehydes, e.g., benzaldehyde, may be separated from liquid hydrocarbons and other neutral, water-insoluble hquid compounds by shaking with a solution of sodium bisulphite the aldehyde forms a sohd bisulphite compound, which may be filtered off and decomposed with dilute acid or with sodium bicarbonate solution in order to recover the aldehyde. 

Footnote 4 - The solubility of Ammonium Chloride in absolute Ethanol is 0.6g/100g at 15C. The solubility in n-Butyl Alcohol is neglible, even at its boiling point. If you use n-Butyl Alcohol, you will only need to perform 3 reflux/filter operations to obtain sufficiently pure Methylamine Hydrochloride. 

A comparison of the relative basicities of pyrrole, furan and thiophene may be made by comparing the pK values of their 2,5-di-t-butyl derivatives, which were found to be -1.01, —10.01 and —10.16, respectively. In each case protonation was shown by NMR to occur at position 2. The base-strengthening effect of alkyl substitution is clearly apparent by comparison of pyrrole and its alkyl derivatives, e.g. A-methylpyrrole has a pKa. for a-protonation of -2.9 and 2,3,4,5-tetramethylpyrrole has a pK of 4-3.7. In general, protonation of a-alkylpyrroles occurs at the a -position whereas /3-alkylpyrroles are protonated at the adjacent a-position. As expected, electron-withdrawing groups are base-weakening thus A-phenylpyrrole is reported to have a p/sTa of -5.8. The IR spectrum of the hydrochloride of 2-formylpyrrole indicates that protonation occurs mainly at the carbonyl oxygen atom and only to a limited extent at C-5. 

Chemical Name (2-butyl-3-benzofuranyl) [4-[2-diethylamino)ethoxy] -3,5-diiodophenyl]-methanone hydrochloride... 

C) Preparation of Doxepin 1,530 grams of the product from step (B) is suspended in 4.5 liters dry tetrahydrofuran and 6.0 mols of butyl lithium in heptane is added during 1 hour. After an additional 30 minutes, 483 grams of 6,1 I dihydrodibenz-lb.eloxepin-ll-one, prepared as described in Belgian Patent 641,49B, is added to the deep red solution and the reaction was maintained at reflux for 10 hours. Water, 500 ml, is added at room temperature and the solvent is removed in vacuo. The crude residue is treated with 10% hydrochloric acid until acidic (pH 2) and then 1.5 liters benzene is added. After stirring, the mixture separates into 3 phases (an insoluble hydrochloride salt product phase, an aqueous phase and an organic phase). 

Chemical Name 3,4-dimethoxybenzoic acid 4-[ethyl-[2-(4-methoxyphenyl)-1-methylethyl] amino] butyl ester hydrochloride... 

Benoxinate hydrochloride Bumetanide Fluocortin butyl Pentobarbitol sodium p-n-Butoxy acetophenone Dyclonine HCI Butoxybenzyl bromide Butropium bromide 7-[D-0 -tert-Butoxycarbonylamino-a -... 

Penicilloic acid 5, the substrate for the projected lactamization reaction, could be derived from the suitably protected intermediate 6. Retrosynthetic disassembly of 6, in the manner illustrated, provides D-penicillamine hydrochloride (7) and tert-butyl phthalimido-malonaldehydate (8) as potential building blocks. In the synthetic direction, it is conceivable that the thiol and amino groupings in 7 could be induced to converge upon the electrophilic aldehyde carbonyl in 8 to give thiazolidine 6 after loss of a molecule of water. 

Glycine ethyl ester hydrochloride, 14, 46 16, 86 17, 92 Grignard reaction in -butyl ether, 11, 84 with acetaldehyde, 12, 48 with butyl p-toluenesulfonate, 10, 4 with carbon dioxide, 11, 80 with dimethyl sulfate, 11, 66 with ethyl carbonate, 11, 98... 

CN 4-[l-hydroxy-4-[4-(hydroxydiphenylmethyl)-l-piperidinyl]butyl]-a,a-dimethylbenzeneacetic acid hydrochloride... 

CisHisLNjO 154371-62-7) see Eprosartan tert-butyl 4,4 -dimethoxy-a-stilbenyl sulfide (C20H24O2S) see Raloxifene hydrochloride tert-butyl 4,4 -dimethoxy-a-stilbenyl sulfoxide (C20H24O3S 186408-54-8) see Raloxifene hydrochloride l-butyl-2-(2,6-dimethylanilinocarbonyl)pyridinium bromide... 

CiiHnNO 84080-68-2) see Cefixime 17,21-(l-butyl-l-methoxymcthylenedioxy)-3,20-dioxo-9-fluoro-lip-hydroxy-l(Sa-methyl-l,4-pregnadiene (C2gH3gF06 1062-64-2) see Dexamethasone valerate S-(crt-butyl 3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-l,4-dihydropyridine-3,5-[Pg.2319]

Ar-(rerr-butyloxycarbonyl)piperidin-4-yl]butyl bromide (C,4H26BrN02 142355-81-5) see Tirofiban hydrochloride -Terr-butyloxycarbonyl-L-threonine... 

C,3H i,N05S 149490-60-8) see Tirofiban hydrochloride rcrt-butyl P-[l,2,3,4-tetrahydro-l,l-bis(phenylthio)-2-oxo-... 

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