Buty lamine

The oral LDso for -butylamine in rats was 372mg/kg versus 228, 152, and 80mg/kg for isobutylamine, rer-butylamine. and tert-buty-lamine, respectively. Signs of toxicity included sedation, ataxia, nasal discharge, gasping, salivation, and death. Pathologic examination showed pulmonary edema. 

The second way differs little from the previous, and consists of the initial formation of 4-hydroxy-3-acetoxybromoacetophenone (11.1.27) by acylation of methyl ester salicylic acid using bromoacetyl chloride. This is also reacted with iV-benzyl-tcrt-buty-lamine, and the resulting product (11.1.28) is completely hydrolyzed by lithium aluminum hydride into the (V-benzyl substituted albuterol (11.1.29), the benzyl group of which is removed by hydrogen over a palladium catalyst to give the desired albuterol (11.1.26) [31]. 

Dobutamine Dobutamine, ( ) 4-[2(4 -hydroxyphenyl)-l-methylpropyl]-3,4-dihydrox-yphenylethylamine (11.1.31), differs significantly from all of the presented drugs in terms of structure, the main difference being the absence of a hydroxyl group at the )3-carbon atom of the phenylethylamine moiety of classic sympathomimetics. The second considerable difference from the examined drugs is the presence of p-hydroxyphenyl-iso-buty-lamine group as a terminal amine substituent. 

Using (S)-PGA as the chiral auxiliary would yield (R)- -aminoindane or, (R)-3,3-dimethyl-2-buty-lamine, respectively. 

See Potassium permanganate Acetone, ZerZ-Buty lamine See other nitroalkanes... 

Carbonyl reduction. The complexes of BH2CN with propylamine or buty-lamine are very efficient and chemoselective reducing agents. 

In Fig. 2 are plotted n-butylamine titers of nickel sulfate at various acid strengths against temperature of heat treatment. The -buty-lamine titers at any acid strength increase with increasing temperature of the heat treatment, attain maxima around 350°, and then decrease. Cupric sulfate also showed similar acidity changes, although the acidity... 

Mobile phaste 1 gal EtOH -I- 77 mL MeCN + 1.9 mL t-butylamine (EtOH MeCN t-buty-lamine 98 2 0.05)... 

FIGURE 2.1 Correlation of equilibrium constants with amine pK (2.1a, top) and gas phase basicity (2.1b, bottom). The filled data points are for aliphatic amines 1. piperidine, 2. n-buty-lamine, 3. n-propylamine, 4. s -butylamine, 5. C6H5CH2NH2, 6. propargylamine, 7. p-toluidine, 8. m-toluidine, and the open data points are for aromatic amines 10. 4-dimethylaminopyridine, 11. 4-methoypyridine, 12. 4-t-butylpyridine, 13. pyridine, 14. 3-methoxypyridine, and 15.3-chloropyridine. 

As mentioned above, Padorek et al. [22] studied the addition of buty-lamine, dibutylamine and triethylamine on model fluoro-compounds. They also studied the reaction between a Viton-A poly(VDF-co-HFP) copolymer and a Kel-F poly(VDF-co-CTFE) copolymer with monoamines [20], in solution of diglyme, at different times and temperatures, and for different amounts of amines ... 

The emulsions of perfluorotributylamine (Fluosol 43) are more stable and can be stored refrigerated at 1-10°C [42,43], but the retention time in organs is very long [69,73]. Perfluorotributylamine is eliminated from blood, probably by storage in tissues. At a dose of 4 g/kg in rats, the half-life of perfluorotri-n-buty-lamine in the body has been estimated to be 900 days. 

---