1- BUTANONE, l-

Chemical Name 1-Butanone, l-(4-fluorophenyl)-4-(4-(2-pyridinyl)-l-piperazinyl)-... 

Butanone, l-(2-furanyl)-, l-(2-furyl)butan-l-one, 2-furylpropyl ketone, 2-butanoylfuran, 2-n-butyrylfuran (4208-57-5]... 

The addition of phenyllithium to 3-hydroxy-l,3-diphenyl-1-butanone (4. R1 = R3 = C6HS R2 = H) leads to the predominant formation of either one or the other diastereomer, depending on the reaction temperature146. Thus, for this type of addition reaction there are at least two competing mechanisms which have quite different activation entropies147. 

CN 4-[4-(2,3-dihydro-2-thioxo- l//-benzimidazol-l -yl)-1 -piperidinyl]-1 -(4-fluorophenyl)- 1-butanone... 

Phenyl-l,3-butanedione, b63 4-Phenyl-2-butanone, b77a Phenyl cellosolve, p72 Phenyl chloride, c47 Phenylcyclohexane, c376... 

This method gives a somewhat tower yield than method 1. Dissolve 14.1 g l-nitro-3-butanone in 30 ml glacial acetic acid and heat to 35° add slowly with stirring to a solution of 5.3 g bromine in 10 ml glacial acetic acid. Evaporate in vacuum, dissolve residue in ether and wash with water, NaHC03 and water. Dry and evaporate in vacuum the ether (can distill 84/2) to get 6 g 1 -nitro-4-Br-3-butanone (1). Add 4.4 g (I) to 25 ml 48% HBr and reflux three hours. Add 50 ml water and steam distill. Neutralize the distillate with K carbonate and extract with ether. Dry and evaporate the extract (can distill 128/20) to get 5.6 g 2-Br-5-Br-methyl-isoxazole... 

The results of the olefin oxidation catalyzed by 19, 57, and 59-62 are summarized in Tables VI-VIII. Table VI shows that linear terminal olefins are selectively oxidized to 2-ketones, whereas cyclic olefins (cyclohexene and norbomene) are selectively oxidized to epoxides. Cyclopentene shows exceptional behavior, it is oxidized exclusively to cyclopentanone without any production of epoxypentane. This exception would be brought about by the more restrained and planar pen-tene ring, compared with other larger cyclic nonplanar olefins in Table VI, but the exact reason is not yet known. Linear inner olefin, 2-octene, is oxidized to both 2- and 3-octanones. 2-Methyl-2-butene is oxidized to 3-methyl-2-butanone, while ethyl vinyl ether is oxidized to acetaldehyde and ethyl alcohol. These products were identified by NMR, but could not be quantitatively determined because of the existence of overlapping small peaks in the GC chart. The last reaction corresponds to oxidative hydrolysis of ethyl vinyl ether. Those olefins having bulky (a-methylstyrene, j8-methylstyrene, and allylbenzene) or electon-withdrawing substituents (1-bromo-l-propene, 1-chloro-l-pro-pene, fumalonitrile, acrylonitrile, and methylacrylate) are not oxidized. 

Lantry, L.E., Zhang, Z., Crist, K.A., Wang, Y., Kelloff G.J., Lubet, R.A. and You, M. (1999) 5-Aza-2 -deoxycytidine is chemopreventive in a 4-(methyl-nitrosamino) -1- (3 -pyridyl) -1 -butanone-induced primary mouse lung tumor model. Carcinogenesis, 20, 343-346. 

C18H20N4O2 3- [(8- [( )-2-hy droxy imino-1 -mediylpropylidene]amino -1 -naphthy l)imino]-2-butanone oxime Ebciraction Cu, Ni 113... 

Comparative metabolism of the tobacco-specific nitrosamines 4-(meth-ylnitrosamino)-1 -(3-pyridyl)-1 -butanone and 4- (methylnitrosam ino) -1 - (3 -pyri-dyl)-l -butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13. Drug Metab Dispos 2003 31(10) 1199-1202. 

Since nicotine is the major precursor to NNN in tobacco and tobacco smoke, the reaction of nicotine with sodium nitrite was studied to provide information on formation of other tobacco specific nitrosamines, especially NNK and NNA, which could arise by oxidative cleavage of the l -2 bonds or l -5 bond of nicotine followed by nitrosation (26). The reaction was investigated under a variety of conditions as summarized in Table I. All three nitrosamines were formed when the reaction was done under relatively mild conditions (17 hrs, 20 ). The yields are typical of the formation of nitrosamines from tertiary amines (27). At 90 , with a five fold excess of nitrite, only NNN and NNK were detected. Under these conditions, both NNK and NNA gave secondary products. NNK was nitrosated a to the carbonyl to yield 4-(N-methyl-N-nitrosamino)-2-oximino-l-(3-pyridyl)-1-butanone while NNA underwent cyclization followed by oxidation, decarboxylation and dehydration to give l-methyl-5-(3-pyridyl)pyrazole, as shown in Figure 4. Extensive fragmentation and oxidation of the pyrrolidine ring was also observed under these conditions. The products of the reaction of nicotine and nitrite at 90 are summarized in Table II. 

In the reaction of 2-cyclohexenone and of 4-phenylbut-3-en-2-one with chiral organocuprates of type (205), optical yields of only 5% and 15%, respectively, were obtained201 . Methylation of l,3-diphenyl-2-propene-l-one with (205) (R = CH3) produced (S)-l,3-diphenyl- 1-butanone in 68% enantiomeric excess 202>. 

Preparation of 2-benzyl-l-[4-(2-hydroxyethylamino)phenyl]-2-dimethyl-amino-1 -butanone... 

The reaction of 1,3-dibromopropane with methyl methylsulfanylmethyl sulfoxide in the presence of base gave cyclobutanone via the intermediate formation of ftve-membered cyclic sulfonium salt 6, which was finally converted to 1-methylsulfinyl-l-methylsulfanylcyclobutane (7 a) by a Stevens-type rearrangement in 70% yield which on acid hydrolysis gave cyclo-butanone.142... 

Methylnitrosamino)-l-(3-pyridyl)-l-butanone [see 4-(-Nitrosomethyl-amino )-1 -(3-pyridyl)-1 -butanone]... 

Hecht SS, Kenney PM, Wang M, Trushin N, Agarwal S, Rao AV, Upadhyaya P. 1999. Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-l-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice. Cancer Lett 137 123-130. 

A. Isopvopylidensaaetophenone. A 1-L, three-necked flask is fitted with a 100-mL pressure-equalizing dropping funnel, a mechanical stirrer and a condenser which is equipped with a two-way stopcock leading to a balloon of argon gas. To the flask is added a solution of 18,4 g of 3-hydroxy-3-methyl-1-phenyl-1-butanone (Note 1) in 60 mL of dry methylene chloride. The flask is cooled 1n an ice bath and 28.5 g of trlethylamine, a catalytic amount of 4-(N,N-dimethylamino)pyridine and 20 mL of methylene chloride are added. A solution of 25.8 g of trlfluoroacetic anhydride (Note 2) in 40 mL of methylene chloride Is added dropwlse over a period of 15 min, and the mixture is stirred for 2. 5 hr. ... 

HEXAHYDRO-4, 4,7-TRIMETHYL-4H-l,3-BEN20XATHIXN 4H-1, 3-BENZOXATHIIN, HEXAHYDRO-4,4, 7-TRIMETHYL- (59324-06-0), 65, 215 Hydrazine, (1,1-diraethylethyl)-, monohydrochloride, 65, 166 Hydrazine, tert-butyl, monohydrochloride, 65, 166 Hydrogen peroxide (7722-84-1), 65, 166 3-HYDR0XY-3-METHYL-1-PHENYL-1-BUTAN0NE 1-BUTANONE,... 

Dimethyl-1-cyclohexyl-1-trimethylsiloxy-ethene (191) gives by means of methyllithium/ethylbromide in dimethoxyethane (DME) 1-cyclohexyl-2,2-dimethyl-1-butanone (297)133 Dimerizations occur when substances such as 1-trimethylsiloxy-styrene (192) or 1-trimethylsiloxy-l-cyclopentene (195) are treated with silver oxide/ DMSO to afford l,5-diphenyl-2,5-butadione (198) and 2,2 -dicyclopentanonyl (199)l34 respectively. Under the catalytic influence of Cu2+ ions, 192 plus ben-zenesulfonyl chloride yield phenyl-(l-phenyl-l-ethanone-2-yl)sulfone (200)l3 ... 

Compound A has three unique carbons in addition to C6H5C=0 and so must be 1-phenyl-l-butanone. Compound B has only two additional signals and so must be 2-methyl-1-phenyl-1-propanone. 

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