Buruli ulcer

Although the clinical use of polyketide-inspired pharmaceuticals has been appreciated for decades, polyketide-derived metabolites have been recognized recently for their role in bacterial virulence. For example, the pathogenesis of Mycobacterium ulcerans, the causative agent of the devastating skin disease known as Buruli ulcer, is the result of the secretion of... 

Outcome skin lesions/Buruli ulcer Virulence Factor... 

Bacterial infections are the other common neglected diseases. They comprise leprosy and trachoma, which are controlled by antibiotic treatments, Buruli ulcer, managed by surgery and antibiotics, cholera, caused by Vibrio cholerae living in contaminated drinking water, and for which antibacterials and isotonic fluid replacement therapy are recommended. 

However, the WHO Innovative and Intensified Disease Management (IDM) group considers only the following as neglected tropical diseases (NTDs) Buruli ulcer, Chaga s disease, cholera, human African tryapanosomiasis and leshmaniasis. They... 

Mycolactones A (71) and B are 12-membered ring macrolides produced by a myxobacterium, Mycobacterium ulcerans [89, 90]. M. ulcerans causes Buruli ulcer, a severe human skin disease that occurs primarily in Africa and Australia. Mycolactones are suggested to play a major role in the pathology of the disease... 

FIGURE 2 A personal account of Captain Grant s odyssey describing the first (suspected) case of Buruli ulcer. 

A detailed account of the history of Mycobacterium ulcerans infection is beyond the scope of this chapter, and the interested reader is redirected to the most comprehensive review on the History, biology, and chemistry of Buruli ulcer that we published at the end of 2013. ... 

As discussed in Section 1, the total synthesis of mycolactone A/B was not our first objective, as we aimed at preparing a library of simplified mycolactone analogs to explore the biology of Buruli ulcer, in collaboration with the fristitut Pasteur (Paris). The synthetic strategy outlined in the previous... 

Fig. 6.23 The structure of mycolactone A/B. Mycolactone is an immunosuppressant toxin produced by selected pathogenic mycobacterial strains and is responsible for the formation of Buruli ulcers. A crucial role exists for a P450 in synthesis of the toxin. Mycolactone A/B is formed through the M. ulcerans CYP140A7-mediated C12 -...

Kishi Y (2011) Chemistry of mycolactones, the causative toxins of Buruli ulcer. Proc Natl Acad Sci U S A 108 6703-6708... 

Chany AC, Tresse C, Casarotto V, Blanchard N (2013) History, biology and chemistry of Mycobacterium ulcerans infections (Buruli ulcer disease). Nat Prod Rep 30 1527-1567... 

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