Mycobacterium ulcerans

Clofazimine is given to treat sulfone-resistant leprosy or to patients who are intolerant to sulfones. It also exerts an antiinflammatory effect and prevents erythema nodosum leprosum, which can interrupt treatment with dapsone. This is a major advantage of clofazimine over other antileprosy drugs. Ulcerative lesions caused by Mycobacterium ulcerans respond well to clofazimine. It also has some activity against M. tuberculosis and can be used as last resort therapy for the treatment of MDR tuberculosis. [Pg.564]

Duker, A.A., Carranza, E.J.M. and Hale, M. (2005) Spatial relationship between arsenic in drinking water and Mycobacterium ulcerans infection in the Amansie West district, Ghana. Mineralogical Magazine, 69(5), 707-17. [Pg.207]

Although the clinical use of polyketide-inspired pharmaceuticals has been appreciated for decades, polyketide-derived metabolites have been recognized recently for their role in bacterial virulence. For example, the pathogenesis of Mycobacterium ulcerans, the causative agent of the devastating skin disease known as Buruli ulcer, is the result of the secretion of... [Pg.1523]

Stinear TP, Mve-Obian A, Small PLC, Frigui W, Pryor MJ, Brosch R, Jenkin GA, Johnson PDR, Davies JK, Lee RE, Adusumilli S, Gamier T, Haydock SF, Leadlay PF, Cole AT. Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans. Proc. Natl. Acad. Sci. U.S.A. 2004 101 1345-1349. [Pg.1534]

Mycolactones A (71) and B are 12-membered ring macrolides produced by a myxobacterium, Mycobacterium ulcerans [89, 90]. M. ulcerans causes Buruli ulcer, a severe human skin disease that occurs primarily in Africa and Australia. Mycolactones are suggested to play a major role in the pathology of the disease... [Pg.22]

Clofazimine (iamprene) hinds preferentially to GC-rich mycobacterial DNA, increases mycobacterial phospholipase Aj activity, and inhibits microbial K transport. It is weakly bactericidal against M. intracellulare. The drug also exerts an anti-inflammatory effect and prevents the development of erythema nodosum leprosum. Clofazimine is recommended as a component of multiple-drug therapy for leprosy. It also is useful for treatment of chronic skin ulcers produced by Mycobacterium ulcerans. [Pg.796]

A Walk Across Africa with Captain Grant Exploring Mycobacterium ulcerans Infection with Mycolactone Analogs... [Pg.85]

A detailed account of the history of Mycobacterium ulcerans infection is beyond the scope of this chapter, and the interested reader is redirected to the most comprehensive review on the History, biology, and chemistry of Buruli ulcer that we published at the end of 2013. ... [Pg.87]

Mycobacterium ulcerans Mycolactone Inhibits human DC maturation and chemotaxis" Inhibits murine macrophage TNF-a production in response to whole bacteria" ... [Pg.7]

Coutanceau E, Dccalf J, Martino A et al. Selective suppression of dendritic cell functions by mycobacterium ulcerans toxin mycolactone. J Exp Med 2007 204(6) 1395-1403. [Pg.17]

Stinear TP, Pryor MJ, Porter JL, Cole ST (2005) Functional analysis and annotation ofthe virulenee plasmid pMUMOOl irom Mycobacterium ulcerans. Microbiology 151 683-692... [Pg.379]

George KM, Chatteijee D, Gunawardana G, Welty D, Hayman J, Lee R, Small PL (1999) Mycolactone a polyketide toxin from Mycobacterium ulcerans required for virulence. Science 283 854-857... [Pg.391]

Hall BS, Hill K, McKenna M, Ogbechi J, High S, Willis AE, Simmonds RE (2014) The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER. PLoS Path 10 el004061... [Pg.391]

Mve-Obiang A, Lee RE, Portaels F, Small PL (2003) Heterogeneity of myeolaetones produced by clinical isolates of Mycobacterium ulcerans implications for virulence. Infect Immun 71 774-783... [Pg.391]

Mve-Obiang A, Lee RE, Umstot ES, Trott KA, Grammer TC, Parker JM, Ranger BS, Grainger R, Mahrous EA, Small PL (2005) A newly discovered mycobacterial pathogen isolated from laboratory colonies of Xenopus species with lethal infections produces a novel form of mycolactone, the Mycobacterium ulcerans macrolide toxin. Infect Immun 73 3307-3312... [Pg.391]

George KM, Pascopella L, Welty DM, Small PL (2000) A Mycobacterium ulcerans toxin, mycolactone, causes apoptosis in guinea pig ulcers and tissue culture cells. Infect Immun 68 877-883... [Pg.391]

Chany AC, Tresse C, Casarotto V, Blanchard N (2013) History, biology and chemistry of Mycobacterium ulcerans infections (Buruli ulcer disease). Nat Prod Rep 30 1527-1567... [Pg.391]

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