2- Bromobenzoic acid 4-bromobenzoate

Benzoic acid, see Anthracene, Biphenyl, 2-Bromobenzoic acid, 2-Bromobenzoic acid, 4-Bromobenzoic acid, 2-Chlorobenzoic acid, 3-Chlorobenzoic acid, 3,5-Dichlorobenzoic acid, Di-n-butyl phthalate, Dicamba, Ethylbenzene, Fluoranthene, 3-Iodobenzoic acid. Naphthalene, Styrene, Permethrin, Toluene, 2,3,6-Trichlorobenzoic acid, oXylene, ro-Xylene, p-Xylene... 

Terephthalic acid has been obtained from a great many /)-disubstituted derivatives of benzene or cyclohexane by oxidation with permanganate, chromic acid, or nitric acid. The following routes appear to have preparative value from />-toluic acid, />-methylacetophenone,2 or dihydro-/)-tolualdehyde by oxidation with permanganate from f>-cymene by oxidation with sodium dichromate and sulfuric acid from />-dibromobenzene or from /i-chloro- or -bromobenzoic acid by heating at 250° with potassium and cuprous cyanides and from />-dibromo-benzene, butyllithium, and carbon dioxide. ... 

Five to ten grams of crude />-bromobenzoic acid can be obtained by acidifying the solution left in the distilling flask. 

Thirty grams of purified 2,4-dihydroxy-5-bromobenzoic acid is refluxed for twenty-four hours with 375 cc. of water, and the resulting solution is filtered, cooled, and extracted with a 400-cc. and a 200-cc. portion of ether. The ether is removed by evaporation, and the 4-bromoresorcinol is dried on a steam bath. The yield of product melting at 100-102° (Note 2) is 22-22.5 g. (90-92 per cent of the theoretical amount). 

Reaetion of several 3-bromobenzoic acids with excess LDA, followed by addition of a benzyl cyanide, gave the product mixtures shown. Suggest a mechanism for the formation of each of these products. 

Cyclocondensation of 2-chloronicotinic acid with 2-amino-5-iodobenzoic acid and methyl 2-amino-4-bromobenzoate in boiling EtOH in the presence of cone. HCl for 18 h gave the 2-iodo and 3-bromo derivatives of 11-0X0-1 l/f-pyrido[2,l-6]quinazoline-6-carboxylic acid (98MIP1, 98MIP2, 99USP5908840, 99USP5914327). 

Brom-. of or combined with bromine bromo- (as Brombenzoeadure, bromobenzoic acid) bromide of (as Brombaryum, barium bromide). -ammoD, tn., ammonium, n. ammonium bromide, -antimon, n. antimony bromide, -arsen, n., -arsem k, tn. arsem c bromide. ather, tn. ethyl bromide, -athyl, n. ethyl bromide. athylen, n. ethylene bromide, athyiformin, n. Pharm.) bromalin. -atom, n. bromine atom, -baryum, n. barium bromide. beere, /. blackberry, brombeerrot, a. blackberry ed. 

A mixture consisting of 22.7 g potassium o-bromobenzoate, 16.6 g 2,6-dichloro-3-methvlani-line, 12 ml N-ethylmorpholine, 60 ml diethylene glycol dimethyl ether, and 1.0 g anhydrous cupric bromide is heated in a nitrogen atmosphere at 145 C to 155°C for 2 hours. The reaction mixture is diluted with 60 ml diethylene glycol dimethyl ether and acidified with 25 ml concentrated hydrochloric acid. The acidic mixture is diluted with 100 ml of water and the liquid phase decanted from the insoluble oil. The insoluble oil is stirred with methanol and the crystalline N-(2,6-dichloro-3-methylphenyl)anthranilic acid which separates is collected and washed with methanol. The product, after recrystallization from acetone-water mixture melts at 248 C to 250°C. 

Bromobenzaldehyde, 17, 20 18, 62 Jl-BttOMOBF.NZALDrACETA.TF, 18, 63 J-Bromobenzoic acid, 17, 21 p-B romobiphenyl, 16, 85 ar-Bromo-iso-caproic acid, 11, 22 a-Bromo-B-caproic acid, 11, 22 Bromocyanogen, 11, 30 /9-Bromoethylamtoe hydrobromide, 18,13, 77... 

Benzoic m-Toluic (Benzoic acid, 3-methyl-] p-Toluic [Benzoic acid, 4-methyl-J 3,5-Dimcthylbcnzoic [Benzoic acid, 3,5-dimcthyl-] p-Chlorobenzoic [Benzoic acid, 4-chloro-] p-Bromobenzoic [Benzoic acid, 4-bromo-J Phthalic [ 1,2-Bcnzcncdicarboxylic acid] Toluene [Benzene, methyl-] (78) m-Xylene [Benzene, 1,3-dimethyl-] (82) />-Xylene [Benzene, 1,4-dimethyl-] (74) Mesitylene [Benzene, 1,3,5-trimethyl-] (82) p-Chlorotolueno [Benzene, l-ehloro-4-methyl-] (94) p-Bromotolucnc [Benzene, l-bromo-4-methyl-] (94) o-Xylene [Benzene, 1,2-dimethyl-] (64)... 

The first microwave-assisted Suzuki reactions involving heteroaromatic skeletons were reported in 1996 [35]. Hallberg et al. Hnked the substrates 4-iodo and 4-bromobenzoic acid to a TentaGel-Rink resin (Scheme 16). Suzuki reactions on these soUd-phase-Unked substrates were easily performed in less than 4 min using a constant microwave irradiation power (45 W) (no temperature control Standard acidic cleavage with TEA yielded the corresponding biaryls with an excellent yield. 

---