Bromo acetyl chloride

Dehydrochlorination of bis(tnfluoromethylthio)acetyl chloride with calcium oxide gives bis(trifluoromethylthio)ketene [5] (equation 6) Elimination of hydrogen chloride or hydrogen bromide by means of tetrabutylammonium or potassium fluoride from vinylic chlorides or bromides leads to acetylenes or allenes [6 (equation 7) Addition of dicyclohexyl-18-crown-6 ether raises the yields of potassium fluoride-promoted elimination of hydrogen bromide from (Z)-P-bromo-p-ni-trostyrene in acetonitrile from 0 to 53-71 % In dimethyl formamide, yields increase from 28-35% to 58-68%... 

Table 2 Polymerization rates (in 10 L mol s ) of CROP of EtOx with different initiators at various temperatures - acetyl chloride (AcCl), acetyl bromide (AcBr), acetyl iodide (Acl), and 2-bromo-2-methylpropanoyl bromide (BrEB/B)...

Finally, Lecomte and coworkers reported the synthesis of mikto-arm star-shaped aliphatic polyesters by implementing a strategy based on click chemistry (Fig. 36) [162]. Firstly, the polymerization of sCL was initiated by a diol bearing an alkyne function. The chain-ends were protected from any further undesired reaction by the esterification reaction with acetyl chloride. The alkyne was then reacted with 3-azidopropan-l-ol. The hydroxyl function located at the middle of the chain was then used to initiate the ROP of sCL and y-bromo-s-caprolactone. Finally, pendant bromides were reacted successfully with sodium azide and then with N, N-dimethylprop-2-yn-l-amine to obtain pendant amines. Under acidic conditions, pendant amines were protonated and the polymer turned out to exhibit amphiphilic properties. 

Hydroxypyridines may be O-acylated using acetyl chloride in triethylamine <2000TL8053> and with a variety of acid chlorides in moderate to good yields in acetone in the presence of potassium carbonate at 0 °C <2003JME2631>. Acetylation of 2-bromo-3-hydroxypyridine has been achieved in 91% yield by heating in acetic anhydride <20000L2291>. 

Bromine-chlorine exchange with pyrazolotropones is rapid in the case of dibromide 142 [by HCl/methanol, substitution of one bromine atom (66BCJ253)], but exchange proceeds slowly and incompletely with a 5-bromo compound [by acetyl chloride/acetic anhydride (61MI2)]. 

Phenyl acetyl chloride benalaxyl, brodifacoum, difenacoum, difethialone, flocoumafen Phenyl bromo acetic acid phentoate... 

Chloro- or 3-bromo-1,2-dithiolium ions are easily hydrolyzed to 1,2-dithiol-3-ones. The same result is achieved in acetic acid, which is transformed into acetyl chloride (Eq. 12). °... 

Androsta-l,4,6-trien-3-ones react with N-bromoamides to give solely the 6)3,7a-dibromo-derivatives with no detectable products of allylic bromination. The 6/5,7a-dibromides eliminated HBr with rearrangement to 4-bromo-l,4-dien-3-ones on treatment with organic bases. 5a,6)5-Dichloro-steroids may be prepared in fair yield from 3)8-acetoxy-5-enes by treatment with a mixture of lead tetra-acetate and acetyl chloride (1 4). ... 

The enantioselective total synthesis of streptazolin (609), a neutral lipophilic antibiotic isolated from cultures of Streptomyces viridochromogenes, utilizes a tandem iminium ion— vinylsilane cyclization of the tartrate-derived 607 together with intramolecular acylation as a way of achieving high stereoselectivity. Heating a mixture of 570 and ( )-4-bromo-4-(tri-methylsilyl)-3-buten-l-amine (605) followed by dehydration with acetyl chloride provides the imide (606) in reproducible yields of 90%. Reduction of 606 with sodium borohydride affords 607, which is refluxed in trifluoroacetic acid to provide, after careful purification, the single bicyclic adduct 608 in 74% yield. This is then transformed in four steps to the desired streptazolin (609) [196] (Scheme 134). 

Chloropropyl acetate has been prepared by heating 1-bromo-3-chloropropane and potassium acetate in glacial acetic acid, and by the action of acetyl chloride on trimethylene chlorohydrin. ... 

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