Breast conservative surgery

I. Gage, A. Recht, R. Gelman, A.J. Nixon, B. Silver, B.A. Bomstein, J.R. Harris (1995). Long-term outcome following breast-conserving surgery and radiation therapy. Int. J. Radiat. Oncol. Biol. Phys., 33(2), 245-251. 

Holland R, Veling SH, Mravunac M, Hendriks JH (1985) Histologic multifocality of Tis, Tl-2 breast carcinomas. Implications for clinical trials of breast-conserving surgery. Cancer 56 979-990... 

Neoadjuvant treatment of breast cancer has traditionally been used in inflammatory breast cancer, mainly in those patients not amenable to radical surgery and radiotherapy. The aim of the treatment is a downstaging of the disease. However, this approach can also be applied to tumors that are not initially suitable for conservative surgery but may become so post-chemotherapy. The overall survival outcomes are similar for the pre- and post-surgery approaches. 

One of the problems in clinical oncology is the determination of nodal metastases in breast cancer patients if there were a marker that could predict this accurately, then more conservative surgery could be performed and more aggressive therapy reserved for those patients with more extensive disease. The identification of increased levels of ErbB-2 mRNA in fine-needle biopsy specimens was predictive of lymph node involvement preoperatively (Anan et al., 1998). Several studies have shown positive correlation between... 

El. Epstein, A. H., Connolly, J. L., Gelman, R., Schnitt, S. J., Silver, B., Boyages, J., Rose, M. A., Recht, A., and Harris, J. R., The predictors of distant relapse following conservative surgery and radiotherapy for early breast cancer are similar to those following mastectomy. Int. J. Radial Oncol. Biol. Phys. 17, 755-760 (1989). 

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