Nodal metastases

A review by Wu et al. revealed consistently better results for [ F]-FDG-PET (sensitivity 85%, specificity 90% and accuracy 88%) versus CT (54%, 85% and 73%, respectively) in detecting internal mammary and/or mediastinal lymph nodal metastases [56]. 

CCR7 Expression by Human Cancers and Its Correlation with Nodal Metastases and Poor Prognosis... 

One of the problems in clinical oncology is the determination of nodal metastases in breast cancer patients if there were a marker that could predict this accurately, then more conservative surgery could be performed and more aggressive therapy reserved for those patients with more extensive disease. The identification of increased levels of ErbB-2 mRNA in fine-needle biopsy specimens was predictive of lymph node involvement preoperatively (Anan et al., 1998). Several studies have shown positive correlation between... 

Accurate molecular detection of melanoma nodal metastases an assessment of multimarker assay specificity, sensitivity, and detection rate. / Clin Pathol Mol Pathol, 56, 43—51. 

Mammaglohin, a potential marker of breast cancer nodal metastases.J Pathol, 189, 28-33. 

The probability of tumor recurrence correlates with the disease stage and is 10%-20% for stages IB and llA with negative lymph nodes and 50%-70% in advanced tumors of stages IIB-IVA and in patients with nodal metastases (Fig. 7.3) [45]. The incidence of pelvic recurrence and metastatic spread is highest during the first 2 years after diagnosis and primary therapy [46]. The true pelvis is the site of recurrent tumor in 60%-80% of cases [44,47-49]. 

Schoder H, Carlson DL, Kraus DH, Stambuk HE, Gonen M, Erdi YE, Yeung HW, Huvos AG, Shah JP, Larson SM, Wong RJ (2006) PET/CT for detecting nodal metastases in patients with oral cancer staged No by clinical examination and CT/MRI. Nucl Med 47 755-762... 

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