Breast cancer resistance protein expression

Sargent, J. M., Williamson, C. J., Maliepaard, M., Elgie, A. W., Scheper, R. J., Taylor, C. G. (2001). Breast cancer resistance protein expression and resistance to daunorubicin in blast cells from patients with acute myeloid leukaemia. Br. J. Haematol. 115,251-261. 

M. Ceckova, A. Libra, P. Pavek, P. Nachtigal, M. Brabec, R. Fuchs, and F. Staud. Expression and functional activity of breast cancer resistance protein (BCRP, ABCG2) transporter in the human choriocarcinoma cell line BeWo. Clin Exp Pharmacol Physiol. 33 58-65 (2006). 

P.L.R. Ee, X. He, D.D. Ross, and W.T. Beck. Modulation of breast cancer resistance protein (BCRP/ABCG2) gene expression using RNA interference. Mol Cancer Ther. 3 1577-1584 (2004). 

T. Janvilisri, H. Venter, S. Shahi, G. Reuter, L. Balakrishnan, and H.W. Van Veen. Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 278 20645-20651 (2003). 

Imai, Y., Nakane, M., Kage, K., et al. (2002) C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q14IK protein and low-level drug... 

Zamber, C. P., Lamba, J. K., Yasuda, K., et al. (2003) Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine. 

Ross DD, Yang W, Abruzzo LV, Dalton, WS, Schneider E, Lage H, Dietel M, Green-berger L, Cole SPC, Doyle AL (1999) Atypical multidrug resistance breast cancer resistance protein messenger RNA expression in mitoxanthrone-selected cell lines. J Natl Cancert Inst 91 429-433... 

Active efflux transporters also exist in the placenta, analogous to the gut and blood-brain barrier. These are Pgp, multidrug resistance-associated protein (MRP), and breast cancer resistance protein (BCRP). These transport proteins are located in many tissues but also appear to be expressed in the placenta. Though the substrate specificities of these proteins have not been completely described, they appear to function as efflux transporters, moving endogenous and exogenous chemicals from the placental cells back to the systemic circulation. In this way, they serve as a mechanism to protect the fetus from exposure to unintended chemicals. 

Xia CQ, Liu N, Yang D, et al. Expression, localization, and functional characteristics of breast cancer resistance protein in Caco-2 cells. Drug Metab Dispos 2005 ... 

Efflux systems of major importance in the intestinal epithelium are P-glycoprotein (P-gp) (Mizuno et al. 2003), multidrug resistance-associated protein 2 (MRP2) (Jansen et al. 1993), and breast cancer resistance protein (BCRP) (Doyle et al. 1998, Doyle and Ross 2003). The latter is described as a half-transporter and possibly functions as a homodimer (Schinkel and Jonker 2003). Details on the molecular weight, structure, substrates, and expression of P-gp, MRP2, and BCRP are listed in Table 3.2. It needs to be mentioned that expression of these intestinal efflux transporter systems shows high... 

Huls M, Brown CD, Windass AS, Sayer R, van den Heuvel JJ, Heemskerk S, Russel FG, Masereeuw R.The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane. Kidney int 2007 73 220-225. Miller DS, Stewart DE, Pritchard JB. Intracellular compartmentation of organic anions within renal cells. Am J Physiol 1993 264 ... 

Pumplin, D.W., Fang, H.B. and Ross, D.D. (2003) Functional characterization of human breast cancer resistance protein (BCRP, ABCG2) expressed in the oocytes of Xenopus laevis. Molecular Pharmacology, 64, 1452-1462. 

Yeboah, D., Sun, M Kingdom, J., Baczyk, D., Lye, S.J., Matthews, S.G. et al. (2006) Expression of breast cancer resistance protein (BCRP/ABCG2) in human placenta throughout gestation and at term before and after labor. Canadian Journal of Physiology and Pharmacology, 84, 1251-1258. 

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