Brainstem auditory evoked potentials

Brainstem auditory evoked potential (BAEP) latency (Holdstein et al. 1986 Otto et al. 1985 Robinson et... 

Robinson GS, Baumann S, Kleinbaum D, et al. 1985. Effects of low to moderate lead exposure on brainstem auditory evoked potentials in children Environmental health document 3. Copenhagen, Denmark World Health Organization Regional Office for Europe, 177-182. 

Robinson GS, Keith RW, Bomschein RL, et al. 1987. Effects of environmental lead exposure on the developing auditory system as indexed by the brainstem auditory evoked potential and pure tone hearing evaluations in young children. In Lindberg SE, Hutchinson TC. eds. International Conference on Heavy Metals in the Environment, Vol. 1, New Orleans, LA. September. Edinburgh, UK CEP Consultants, Ltd., 223-225. 

Murata K, Weihe P, Budtz-Jorgensen E, Jorgensen PJ, Grandjean P (2004) Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercury. J Pediatr, 144(2) 177-183. 

Church MW, Overbeck GW. Prenatal cocaine exposure in the Long-Evans rat III. Developmental effects on the brainstem-auditory evoked potential. Neurotoxicol Teratol 1990 12 345-51. 

Guerit JM, Mahieu P, Houben-Giurgea S, Herbay S. The influence of ototoxic drugs on brainstem auditory evoked potentials in man. Arch Otorhinolaryngol 1981 233(2) 189-99. 

Discalzi G, Fabbro D, Meliga F, et al. 1993. Effects of occupational exposure to mercury and lead on brainstem auditory evoked potentials. Int J Psychophysiol 14(l) 21-25. 

Hirata M, Ogawa Y, Okayama A, et al. 1992a. A cross-sectional study on the brainstem auditory evoked potential among workers exposed to carbon disulfide. Int Arch Occup Environ Health 64(5) 321-324. 

In contrast to the Hake and Stewart (1977) study, Altmaim et al. (1990) found a statistically significant (p<0.05) increase in latency of pattern reversal visual-evoked potentials in 10 male volunteers exposed to tetrachloroethylene at 50 ppm for 4 hours/day for 4 days, relative to 12 subjects exposed at 10 ppm. No effects on brainstem auditory-evoked potentials were noted. Tests of visual contrast measured in a few individuals showed a tendency for loss of contrast in the low and intermediate spatial frequencies at 50 ppm. In this study, measurements were also completed the day before exposure so each individual served as his own control. The 10-ppm group was considered the control group, and this concentration was used because it is well above the odor threshold of tetrachloroethylene so that there was at least an attempt to blind the subjects to the exposure concentrations. Blood tetrachloroethylene concentrations were measured before, in the middle, and at the end of each day s exposure, and an association between the effect on pattern reversal visual-evoked potentials and blood tetrachloroethylene concentrations was observed (p<0.03). The lack of effect on flash visual-evoked potentials in the Hake and Stewart (1977) study at concentrations up to 100 ppm compared to an effect on pattern reversal visual-evoked potentials at 50 ppm in the Altmann et al. (1990) study may reflect the greater inter- and intrasubject variability of waveforms for flash visual-evoked potentials (Otto et al. 1988). 

In a similar study by Altmann et al. (1990), significant (p<0.05) increased latencies for pattern reversal visual-evoked potentials were observed in 10 male volunteers exposed to tetrachloroethylene at 50 ppm, compared to 12 men exposed at 10 ppm. Exposures in this study were also 4 hours/day for 4 days. Effects on brainstem auditory-evoked potentials were also not observed in the Altmann et al. (1990) study. Tetrachloroethylene in the blood increased with exposure duration, and linear regression to associate blood tetrachloroethylene with pattern reversal visual-evoked... 

Bleecker, M.T., D.P. Ford, K.N. Tindgren, K. Scheetz, and M.J. Tiburzi. 2003. Association of chronic and current measures of lead exposure with different components of brainstem auditory evoked potentials. Neurtoxicology 24(4-5) 625-631. Bleecker, M.T., D.P. Ford, K.N. Tindgren, V.M. Hoese, K.S. Walsh, and C.G. Vaughan. 2005a. Differential effects of lead exposure on components of verbal memory. Occup. Environ. Med. 62(3) 181-187. 

Slowed brainstem auditory evoked potentials (mean CBLI = 723-934 pg-years/dL). 

Lead exposme interferes with brainstem auditory evoked potentials in dose-dependent manner. 

These children were also evaluated through electrophysiological means. Otto et al. (1981) reported a significant linear association between PbB and slow-wave voltage. In a follow-up of this group after 5 years (Otto et al., 1985), the relationship of slow-wave responses to PbB along with a significant association of pattern-reversal evoked potentials (PREPs) and brainstem auditory evoked potentials (BAEPs) with PbB persisted. 

Bleecker, M.L., Lindgren, K.N., Scheetz, K., Tiburzi, M.J., 2003. Associations of chronic and current measures of lead exposure with different components of brainstem auditory evoked potentials. Neurotoxicology 24, 625—631. 

There was a temporal relation between papaverine and changes in brainstem auditory evoked potentials, leading to waveform loss. Other cases have been reported, as have patients with focal seizures [150. ... 

Electroencephalogram measures have been shown to be sensitive to some forms of neurological insult, and they have been used in the diagnosis of a variety of neurological disorders. Other neurophysiological measures, such as brainstem auditory evoked potential (BAEP), and pattern-reversal visual evoked potential (PREP), are supposed to be stable, relatively age-independent, and free from social or cultural influences. 

In addition to the experimental conditioning tests, Otto et al (1985) used two clinically validated measures of sensory function, the pattern-reversal visual evoked potential (PREP) and the brainstem auditory evoked potential (BAEP). Exploratory analysis of PREPs revealed increased amplitude and decreased latency of certain components as a linear function of original PbB levels. Although these results were contrary to predictions, the findings are consistent with the results of Winneke et al (1984), who found an association between increased PbB levels and decreased latency in the primary positive component of PREPs in children. BAEP results of the five-year follow-up study also indicated significant associations between original PbB levels and increased latencies of two components (waves III and V), indicative of auditory nerve conduction slowing. 

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