Brain AMPA receptor subunits

Structure and Distribution of AMPA Receptor Subunits in Brain... 

Sun H., Kawahara Y., Ito K., Kanazawa I., and Kwak S. (2005). Expression profile of AMPA receptor subunit mRNA in single adult rat brain and spinal cord neurons in situ. Neurosci. Res. 52 228-234. 

Akbarian S., Smith M. A., and Jones E. G. (1995). Editing for an AMPA receptor subunit RNA in prefrontal cortex and striatum in Alzheimer s disease, Huntington s disease and schizophrenia. Brain Res. 699 297-304. 

Chen LW, Wei LC, Lang B, Ju G, Chan YS (2001) Differential expression of AMPA receptor subunits in dopamine neurons of the rat brain a double immunocytochemical study. Neuroscience 70(5 149-160. 

Gold SJ, Ambros-Ingerson J, Horowitz JR, Lynch G, Gall CM (1997) Stoichiometries of AMPA receptor subunit mRNAs in rat brain fall into discrete categories.. 1 Comp Neurol iS5 491-502. 

D Aldin C, Caicedo A, Ruel J, Renard N, Pujol R, Fuel JL (1998) Antisense oligonucleotides to the GluR2 AMPA receptor subunit modify excitatory synaptic transmission in vivo. Brain Res Mol Brain Res 55 151-164. 

Matsubara A, Takumi Y, Nakagawa T, Usami S, Shinkawa H, Ottersen OP (1999) Immunoelectron microscopy of AMPA receptor subunits reveals three types of putative glutamatergic synapse in the rat vestibular end organs. Brain Res S79 58-64. 

AMPA receptors are believed to mediate most of the fast excitatory neurotransmission in the brain, including the cerebellum. Concordantly the types of AMPA receptor subunits expressed by a cell largely determine the characteristics of the fast excitatory responses (see Jonas and Spruston, 1994). The GluR2 subunit dominate the AMPA receptor channel behavior, in that homomeric GluR2 channels as well as heteromeric... 

Another mechanism of synaptic dysfunction in AD may involve amyloid ft peptide (Aft a 40 to 42 amino acid peptide). A marked increase in Aft levels occurs in brain tissue from AD patients. A ft inhibits glutamatergic neurotransmission and reduces synaptic plasticity (Snyder et al., 2005). Treatment of cortical neuronal cultures with Aft facilitates endocytosis of NMDA receptor. Aft-mediated endo-cytosis of NMDA receptor requires the a-1 nicotinic receptor, protein phosphatase 2B, and the tyrosine phosphatase STEP. Dephosphorylation of the NMDA receptor subunit NR2B at Tyrl472 correlates with receptor endocytosis. The addition of a y-secretase inhibitor not only reduces Aft but also restores surface expression of NMDA receptors, suggesting that A plays an important role in the regulation of NMDA and AMPA receptor trafficking (Snyder et al., 2005 Morishita et al., 2005). 

Suzuki T, Ito J, Takagi H, Saitoh F, Nawa H, et al. 2001. Biochemical evidence for localization of AMPA-type glutamate receptor subunits in the dendritic raft. Brain Res Mol Brain Res 89 20-28. 

Garci a-Barcina JM, Matute C (1998) AMPA-selective glutamate receptor subunits in glial cells of the adult bovine white matter. Mol Brain Res 55 270-276. 

Martin LJ, Blackstone CD, Levey AI, Huganir RL, Price DL (1993a) AMPA glutamate receptor subunits are differentially distributed in rat brain. Neuroscience 53 327-358. 

Popper P, Rodrigo JP, Alvarez JC, Lopez I, Honrubia V (1997) Expression of AMPA-selective receptor subunits in the vestibular nuclei of the chinchilla. Mol Brain Res 44 21-30. 

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