Boronic acid-containing

Boronic acid-containing polyaniline has also been utilized in diabetes-related research. One such polymer (23) (Fig. 17) has been observed to exhibit a linear near-infrared optical response to saccharides.43 The polymer was prepared by the copolymerization of aniline with 3-aminophenylboronic acid using lOmM (NH4)S208 in 1M HC1. The films were observed to undergo changes in the absorption spectra on addition of saccharides at pH 7.2. 

Figure 17 Boronic acid-containing polyanilines (23 and 24) used in the detection of saccharides. (Adapted from refs. 43 and 44.)...

Figure 140. Binding of saccharides to a boronic-acid containing receptor. Reprinted with permission from Takeuchi, M. Kijima, H. Hamachi, I. Shinkai, S. Bull. Chem. Soc. Ipn. 1997, 70, 699.

A. Boronic Acid-Containing Binding Site Functional Monomers... 

Scheme 1 Synthesis of the boronic acid-containing functional monomer 18.

Maeda, D. Y., Peck, A. M., Schuler, A. D., Quinn, M. T., Kirpotina, L. N., Wicomb, W. N., et al. (2015). Boronic acid-containing CXCRl/2 antagonists Optimization of metabolic stability, in vivo evaluation, and a proposed receptor binding model. Bioorganic Medicinal Chemistry Letters, 25(11), 2280-2284. http //dx.doi.org/ 10.1016/j.bmcl.2015.04.041. 

Ehnas had detailed a temperature-sensitive copolymer, which contained boronic acid units its interaction with ARS and loss of flnorescence upon exposure to a series of analytes was discnssed. " However, boronic acid containing hydrogels that had been developed for electrophoresis applications (discnssed later) were reasoned to be snit-able in the stationary phase for a similar supported system. Thus, this platform allows a dye displacement assay to be performed. " ... 

Structure and Molecular Recognition of Boronic Acid-Containing Polymers... 

A label-free detection of saccharides was proposed by Chung et A boronic acid-containing copolymer was prepared from APBA and acrylamide. The polymer was mixed with a cationic platinum complex 49 in aqueous solution buffered at pH 9.0, and the fluorescence spectra were recorded by excitation at 448 nm. In the absence of saccharides, an emission band at 577 nm is observed. With increasing glucose concentration, this band decreases while a new emission band at 800 nm grows. These spectral changes are caused by the saccharide-induced aggregation of cationic 49 onto the anionic boronate polymer. 

Boronic Acid-Containing Hydrogels Synthesis and Their Applications... 

Synthesis and Properties of Boronic Acid-Containing Hydrogels... 

---