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Bone morphogenetic protein-incorporated

Li et al. [83] fabricated silk fibroin fiber scaffolds containing bone morphogenetic protein 2 (BMP-2) and/or nanoparticles of hydroxyapatite (nHAp) by electrospinning. These scaffolds were used in vitro to study bone formation from hMSCs. The results showed that the incorporation of BMP-2 and/or nHAp into silk... [Pg.222]

Liu, Y., Hunziker, E.B., Layrolle, P., de Bruijn, J.D., and de Groot, K. (2004) Bone morphogenetic protein 2 incorporated into biomimetic coatings retains its biological activity. Tissue Eng., 10 (1-2), 101-108. [Pg.66]

Yamamoto, M., Ikada, Y., Tabata, Y., 2014. Ultrastructure of bone tissue ectopically regenerated by biodegradable hydrogels incorporating bone morphogenetic protein 2. Inflamm. Regen. 34 (1), 056—063. [Pg.54]

Figure 4.4 Design and fabrication of the osteophilic multilayer architecture. Components of the film (a) Chitosan (75-85% deacetylated chitin) a polycation (b) Poly(acrylic acid) (PAA) (c) A hydrolytically degradable poly(p-amino ester) (Poly2), a polycation and (d) osteoinductive recombinant human bone morphogenetic protein 2 (rhBMP-2) (e) Schematic of the modular electrostatic assembly. Osteoconductive hydroxyapatite (HAP) is complexed with chitosan and incorporated into nanoscale thick films along with poly(acrylic acid) in a bilayer architecture. A hydrolytically degradable poly(P-amino ester)-based multilayer fihn incorporating osteoinductive rhBMP-2 lays atop the osteoconductive layer, (f)... Figure 4.4 Design and fabrication of the osteophilic multilayer architecture. Components of the film (a) Chitosan (75-85% deacetylated chitin) a polycation (b) Poly(acrylic acid) (PAA) (c) A hydrolytically degradable poly(p-amino ester) (Poly2), a polycation and (d) osteoinductive recombinant human bone morphogenetic protein 2 (rhBMP-2) (e) Schematic of the modular electrostatic assembly. Osteoconductive hydroxyapatite (HAP) is complexed with chitosan and incorporated into nanoscale thick films along with poly(acrylic acid) in a bilayer architecture. A hydrolytically degradable poly(P-amino ester)-based multilayer fihn incorporating osteoinductive rhBMP-2 lays atop the osteoconductive layer, (f)...
The 3D structure of the electrospun scaffolds should allow the cells to be fully differentiated and should permit them to migrate freely. The influence of 3D PEEA nanofibre scaffolds on in vivo bone formation was studied by Schofer et besides the effect of the incorporation of bone morphogenetic protein 2 (BMP-2) to enhance efficiency. BMP-2 is involved in the development of bone and cartilage tissues and induces osteoblast... [Pg.185]

In addition to the incorporation of bioceramics, such as HA and p-TCP, signalling molecules, such as bone morphogenetic proteins (BMPs), have been incorporated into PLGA/HA and poly-L-lactic acid (PLLA)/HA ... [Pg.485]

Han, D., Liu, W., Ao, Q., Wang, G. Optimal delivery systems for bone morphogenetic proteins in orthopedic applications should model initial tissue repair structures by using a heparin-incorporated fibrin-fibronectin matrix. Med. Hypotheses 71(3), 374-378 (2008)... [Pg.65]

The use of osteoconductive agents is one of the ways to cure bone-related diseases. Bone morphogenetic protein-2 (BMP-2) has been proven as one of the best proteins to solve several bone-related diseases. Stem ceU incorporation in the composite scaffold is a better way to improve the function of bone scaffold nHA with chitosan with bone... [Pg.167]

Cheng et al. [113,114] developed composite scaffolds made of TCP-PLGA by a low-temperature rapid prototyping technique, as shown in Fig. 15.5. The scaffold incorporated either endogenous bone morphogenetic protein-2 (BMP-2)... [Pg.353]

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