Bone and joint infection

If the wound is associated with significant cellulitis and edema, systemic signs of infection, or possible joint or bone involvement, hospitalization and IV antibiotics (typically ampicillin-sulbactam 3 g IV every 6 hours) should be initiated. Bone and joint infections will require longer durations of therapy of up to 6 weeks.44... 

Antibiotics should be used in high-risk patients who develop bacteremia (i.e., infants younger than 3 months and patients with cirrhosis or iron overload) or in patients with bone and joint infections. 

Bone and joint infections 150 mg/kg/day (not to exceed maximum adult dose) in equally divided doses every 8 hours. 

Bone and joint infections - E. faecalis S. aureus (penicillinase-producing), S. epidermidis, Enterobacter sp., P. aeruginosa. 

Bone and joint infections - Caused by Bacteroides sp. including the 6. fragilis group, as adjunctive therapy. 

I.C.4. Skin, Soft Tissue, Bone and Joint Infections... 

The use of fluoroquinolones in bone and joint infections is influenced by the causative agent and the rate of resistance development. The use of the oral route for administration of the fluoroquinolones is especially ad-... 

Unlabeled Uses Treatment of bone and joint infections Contraindications None known Side Effects... 

Uncomplicated pneumonia, skin and skin-structure infections IV, IM 0.5- Ig q 12h. Bone and joint infections IV, IM 2gqI2h... 

I Indications and Dosages Penicillins maybe used to treat a large number of infections, including pneumonia and other respiratory diseases, urinary tract infections, septicemia, meningitis, intra-abdominal infections, gonorrhea, syphilis, and bone and joint infections. 

It is excreted unchanged in urine. It is indicated in respiratory, genitourinary, skin and soft tissue infections, bone and joint infections, dental and ENT infections. 

It is used in respiratory, genitourinary infections including gonorrhoea, septicemia, meningitis, endocarditis surgical, abdominal, bone and joint infections preoperative prophylaxis in those at increased risk of infection and CNS infections. 

It is indicated in upper and lower respiratory tract infections, skin infections, septicaemia, bone and joint infection including acute haematogenous osteomyelitis. 

Duration of therapy is usually 7 to 14 days bone and joint infections may require therapy for 4 to 6 weeks infectious diarrhea may be treated for 5 to 7 days... 

Indications Lower respiratory infection Bone and joint infection Skin and skin structure infection Urinary tract infection Infectious diarrhea Acute sinusitis Prostatitis Typhoid fever Complicated intra-abdominal infection Gonorrhea... 

Ciprofloxacin is approved for use in the treatment of bone and joint infections, infectious diarrhea caused by Shigella or Campylobacter, lower respiratory tract infections, skin infections, and urinary tract infections. It is the drug of choice for the treatment of infections caused by Campylobacter jejuni. In addition, it has found off-label use as an alternative drug for the treatment of gonorrhea, salmonella, and yersinia... 

Cefoxitin Cefotetan Mefoxin Cefotan IV, IM Perioperative prophylaxis in abdominal surgery, treatment of intra-abdominal infections, urinary tract infections, gynecological infections, septicemia, bone and joint infections, skin infections, lower respiratory infections... 

Teicoplanin has been snccessfnUy nsed to treat bone and joint infections withont any adverse reactions affecting bones or joints (42). 

LeFrock J, Ristuccia A. Teicoplanin Bone and Joint Cooperative Study Group A. Teicoplanin in the treatment of bone and joint infections An open study. J Infect Chemother 1999 5(l) 32-9. 

Weinberg WG. Safety and efficacy of teicoplanin for bone and joint infections results of a conununity-based trial. South Med J 1993 86(8) 891-7. 

Oral fluid and electrolyte replacement is an important initial approach. Owing to the self-limiting nature of the illness, antibiotics may not alter the time to resolution of the diarrhea or the rate of bacteriologic cure. Antibiotics should be used in high-risk patients who develop bacteremia (i.e., infants younger than 3 months of age and patients with cirrhosis or iron overload) or in patients with bone and joint infections. ... 

Drugs of choice are not yet identified. Fluoroquinolones alone or in combination with third-generation cephalosporins or aminoglycosides may be effective for Yersinia bacteremia or for those with bone and joint infections. Other antibiotics effective in vitro are chloramphenicol, tetracyclines, and trimethoprim-sulfamethoxazole. Agents frequently resistant to Yersinia are penicillin G, ampicUlin, and first-generation cephalosporins. 

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