Blood platelet-aggregation

Therapeutic Function Blood platelet aggregation inhibitor... 

The patent literature covers many pyridazine derivatives claimed as blood platelet aggregation inhibitors and antithrombotic agents. The interest has been focused mainly on 6-aryl-4,5-dihydro-3(2//)-pyridazinones. In these compounds the aryl substituent has been varied within a wide range. Thus, dihydro-pyridazinones bearing a substituted or heterocycle-fused phenyl group at C-6 (60, R R2,R3 = H, alkyl Ar = substituted Ph) [34, 110-112,205-233] as well as various heteroaryl substituted congeners (61, R1, R2, R3 = H, alkyl Ar = pyridyl, thienyl, pyrrolyl, pyrazolyl) [234-241] have been prepared in search of novel antithrombotics. 

A contact dermatitis occurs infrequently. Because feverfew also inhibits human blood platelet aggregation, interactions are possible with antithrombotic medications such as aspirin or warfarin (Groenewegen and Heptinstall 1990). Abrupt discontinuation of feverfew by people taking it chronically for treatment of migraine can produce rebound withdrawal symptoms. These consist of migraines, anxiety, poor sleep patterns, and stiffness of the muscles and joints. 

Blood/gout/ botrocetin/ polypept./fosta-mg blood platelet aggregation... 

Lawson LD, Ranson DK, Hughes BG. Inhibition of whole blood platelet-aggregation by compounds in garlic extracts and commercial garlic products. Thromb Res 1992 65 141-156. 

Compounds 5 are used as neoplasm inhibitors (89EGP270711) and 14 as vasodilators, anticholesteremics, and blood platelet aggregation inhibitors [81JAP(K)81/127383]. Significant activity against histamine-induced bron-... 

Lorenzo s oil affected blood platelet counts in 39 patients followed for 1 year (2). Blood platelet aggregation studies in those patients were normal and there were no platelet-associated immunoglobulins. It has been suggested that the thrombocytopenia might be due to platelet activation, resulting from an increase in the concentration of erucic acid in the platelet membrane (1). 

Condensation of cyclopentenone with the same precursor under the same conditions gives a high yield of lV-benzyl-3-azabicyclo[3.3.0]-octa-8-one, which serves as a building block for the elaboration of two compounds having the 6-azaprocycline skeleton, compounds which have shown weak inhibitory activities in blood platelet aggregation.427... 

A group of 3-oxoisothiazolopyrimidines (164) have been patented for their ability to inhibit human blood platelet aggregation (77GEP2718707). 3,6-Dialkylisothiazolo[3,4-d]pyrimidin-4(5H)-ones (165) show useful herbicidal activity (73GEP2249099). 

Anthocyanins could act against carbon tetrachloride-induced lipoperoxi-dation. Anthocyanins could also reduce the incidences of fragility of capillaries, inhibit blood platelet aggregation, and strengthen the collagen matrix which is a component of the connective tissues [6]. 

Prostaglandins have many effects they lower blood pressure, affect blood platelet aggregation, affect kidney function and stimulate uterine contractions. 

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