Blood macrophages

TABLE I Total Nitric Oxide (Micromolar) Production by Human Adult Blood Macrophages, Fetal Microglia, and Fetal Mixed Glial Cells... 

Blood macrophages were purified from whole blood collected from a normal adult volunteer. Cells (5 X 10 ) were seeded into a 24-well plate and stimulated with a combination of interferon-y (IFN-y) (500 U/ml) and interleukin-1/8 (IL-1)3) (300 U/ml) for 4 days. Cell supernatants were removed and assayed for total nitric oxide in the laboratory of L. J. Ignarro, UCLA, Los Angeles (Mitrovic et al., 1994). 

Very early after ischemia neutrophils infiltrate the ischemic brain area. Neutrophil infiltration is later followed by blood macrophages, natural killer cells and Tcells [61]. 

PDE4 in primary blood macrophage cultures and in a human monocyte cell line THP-1, whereas in cultured U937 mononuclear cells, PDE4 PDE3. 

The very early peak of neutrophil invasion into an inflamed area is followed several hours later by a wave of a second class of phagocytic cells, the macrophages. This biphasic pattern of inflammatory cell movement and accumulation is observed in most acute inflammatory responses. The mononuclear phagocyte in the blood is known as the monocyte and differentiates... 

White blood cell preferentially located near potential entry sites for microbial pathogens and specialized for the uptake of particulate material by phagocytosis. Most macrophages originate from peripheral blood monocytes and are able to leave the circulation following stimulation by chemotactic agents. 

Kanke, M., MorUer, E., Geissler, R., Powell, D., Kaplan, A., and DeLuca, P. P., Interaction of microsheres with blood constituents. II. Uptake of biodegradable particles by macrophages, J. Parent. Sci. Technol., 40. 114, 1986. 

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