Blood Cerebrosides

Cerebroside—Fatty substance that fills up blood cells in Gaucher disease. 

However, in the kidney the maximum incorporation had been attained 24 hours after injection, and the radioactivity was still present on the 32nd day. In the brain the 35S-substance sedimented with mitochondria in the kideny with microsomes and in the liver it was found in the soluble fraction. No cerebroside sulphate has been observed in rat blood cells or plasma. 

Galactose is found primarily as a component of lactose, a disaccharide present in the milk of mammals, and in the galactolipids or cerebrosides, which occur in large amounts in the white matter of brain and the myelin sheath of nerves. Mannose occurs widely in plants and is also found in small amounts in animals as a component of such complex materials as glycoproteins, glycolipids and blood group substances. 

Kirk, E. The concentration of lecithin, cephalin, etherinsoluble phosphatide and cerebrosides in plasma and red blood cells of normal adults. J. biol. Chem. 123, 637 (1938). 

For many years GC were not found in the central nervous system, until Teiltjm (1944), Bird (1948) and later others (Deere et al. 1951, Barlow 1957) unequivocally demonstrated their presence. When they occur they are found either isolated within the brain tissue or in connection with the adventitia of small blood vessels, as emphasized by Barlow (1957) and by Diezel (1957), who showed in 1960 that they contained cerebrosides. GC may cause insufficient oxygenation of brain tissue by interference with vascular dilatation and with diffusion (Herrlin and Hillborg 1962), but they can hardly account for the majority of... 

Ottenstein, B., G. Schmidt, and S. J. Thannhauser The variety of cerebrosides present in one case of infantile Gaucher s disease and 3 cases in adults. Blood 3, 1250 (1948). 

There are no characteristic abnormalities of serum or of formed blood elements in ML. Non-specific hypercholesterolemia has been seen (Hagberg 1963), but sulfatides are present in normal amounts (Svennerholm and Svennerholm 1962). The ratio of cerebrosides sulfatides, which is abnormal in the central nervous system, is normal in serum (Hagberg 1963). Some relevant serum enzymes have been studied by Austin et al. (1965 a, b). According to these authors acid phosphatase activity was normal when measured with p-nitrophenylphosphate as substrate. The activity of arylsulfatase B was three to four times that of type A, and thus similar to findings in normal serum. 

Cerebroside, diglycosylceramide, triglycosylceramide, and globoside have been identified in rabbit aorta, plasma, and red-blood cells. The levels of incorporation of 2-PH]acetamido-2-deoxy-D-mannose into the sialic acids of the principal gangliosides of rabbit retina have been investigated. ... 

Yamakawa, 1968 Tamai and Yamakawa, 1968). In the kidneys as well as in intestine (C. Suzuki et al., 1968) Gal-Cer and Glc-Cer occur in comparable concentrations (Martensson, 1966a), whereas in other sources, e.g., lung, milk, and blood (Table III) Glc-Ger may be the predominant cerebroside (Table II). In the kidneys of rats and mice Glc-Ger and Gal-Ger occur in a ratio of ca. 3 1 (Adams and Gray, 1968). The monohexosyl ceramide of human leukocytes was found to be Gal-Cer (Miras et al., 1966). In human blood plasma 20% of the monohexosyl ceramides consist of Gal-Cer (Table III). 

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