Blood-brain barrier structure

C. Pericellular Cell Passage across Blood-Brain Barrier Structures... 

Abbott NJ. Blood-brain barrier structure and function and the challenges for CNS drug delivery. / Inherit Metab... 

Abbott, N. J. Blood-Brain Barrier Structure and Function and the Challenges for CNS Drug Delivery. /owma/ cf Inherited Metabolic Disease 36 (2013) 437- 9. 

Immunocytochemical Assessment of Blood-Brain Barrier Structure, Function, and Damage... 

Blood-brain barrier permeation of 7, among other drugs, was predicted from its three-dimensional molecular structure by a computational method (0OJMC2204). The combination of molecular topological methods using 137 quinolones, including 7 provided an excellent tool for the design of new... 

Molecular structure has been shown to influence absorption. By examining the structural characteristics of drugs that were in use, certain common characteristics of well-absorbed molecules were identified, commonly referred to as the rule of five. Some investigators have used this as a basis for characterizing the drug-likeness of a lead chemical. Other factors also come into play including receptor activity, metabolism profile and for CNS-active compounds, an ability to cross the blood-brain barrier. 

Crivori, P., Crudani, G., Carrupt, P.-A., Testa, B. Predicting blood-brain barrier permeation from three-dimensional molecular structure. J. Med. Chem. 2000, 43, 2204-2216. 

The significance of the barrier function of membranes has been the topic of considerable research. The blood-brain barrier and the blood-retinal barrier are well understood, and the microscopic structures imparting and controlling barrier properties have been quite thoroughly investigated and the science reviewed [15, 154-155], The structures and functions of ocular membranes specific to transport associated with ophthalmic drug administration also have been topics of extensive research [15, 157-158],... 

Smith, B. J., Doran, A. C., Mclean, S., Tingley III, F. D., O Neil, C. A., Kajiji, S. M., P-glycoprotein efflux at the blood-brain barrier mediates differences in brain disposition and pharmacodynamics between two structurally related neurokinin-1 receptor antagonists, J. Pharmacol. Exp. Ther. 2001, 298, 1252-1259. 

Reese, T. S. and Kamovsky M. I. Fine structural localization of a blood-brain barrier to exogenous peroxidase. /. Cell Biol. 34 207-217,1967. 

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