Blood-brain barrier integrity

Guy, J., Ellis, E., Hope, G. and Rao, N.A. (1989b). Antioxidant enzymes reduce loss of blood-brain barrier integrity m experimental optic neuritis. Arch. Ophthalmol. 107, 1359-1363. [Pg.140]

Related to the post-traumatic microvascular damage is the pathophysiological process of vasogenic brain edema that represents a disruption of blood-brain barrier integrity, resulting in sodium and protein accumulation and osmotic fluid expansion of the brain extracellular space. Clinically, this is reflected by an increase in intracranial pressure which, if unchecked, can cause secondary compressive injury to vital brain structures. [Pg.229]

Beauchesne E, Desjardins P, HazeU AS, Butterworth RE (2009) eNOS gene deletion restores blood-brain barrier integrity and attenuates neurodegeneration in the thiamine-deficient mouse brain. J Neurochem 111 452-459... [Pg.120]

Kanmogne GD, Schall K, Leibhart J, Knipe B, Gendelman HE, Per-sidsky Y (2007) HIV-1 gpl20 compromises blood-brain barrier integrity and enliance monocyte migi ation across blood-brain barrier Implication for viral neuropathogenesis. J Cereb Blood Plow Metab 27 123-134. [Pg.309]

Fenart L, Buee-Scherrer V, Descamps L, Duhem C, Poullain MG, et al. 1998. Inhibition of P-glycoprotein rapid assessment of its implication in blood-brain barrier integrity and drug transport to the brain by an in vitro model of the blood-brain barrier. Pharm. Res. 15(7) 993-1000... [Pg.651]

Daneman R, Zhou L, Kebede AA, Barres BA (2010) Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature 468(7323 ) 562-566... [Pg.165]

Sung, X., Pope, C Murthy. R., Shaikh, J., Lai, B and Bressler, J. P. (2004). Interactive cffecLs of paraoxon and pyridostigmine on blood-brain barrier integrity and cholinergic toxicity. Toxicol Sci. 78, 241-247. [Pg.289]

Lockman, PR., Koziara, J.M., Mumper, R.J., Allen, D.D., 2004. Nanoparticle surface charges alter blood-brain barrier integrity and permeability. Journal of Drug Targeting 12, 635-641. [Pg.44]

Alvarez, J.I., Dodelet-Devillers, A., Kebir, H., et al., 2011. The hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science 334, 1727-1731. [Pg.737]

The steady-state programmed infusion technique (Pratt, 1985) was used to assess blood-brain barrier integrity and to measure regional brain uptake of glucose in both lead exposure models. [Pg.456]

Rubio-Araiz A, Perez-Hernandez M, Urrutia A et al (2014) 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) disrupts blood-brain barrier integrity through a mechanism involving P2X7 receptors. Int J Neuro-psychopharmacol 14 1-13... [Pg.252]

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