Block copolymers drug delivery

VPGEG(IPGAG)4]i4-[VPGFG(IPGVG)4]i4 ELP (Block Copolymer) Drug Delivery [93]... 

Mahmud A, Xiong X-B, Lavasanifar A (2006) Novel self-associating poly(ethylene oxide)-block-poly(E-caprolactone) block copolymers with functional side groups on the polyester block for drug delivery. Macromolecules 39 9414-9428... 

Zentner GM, Rathi R, Shih C, et al. Biodegradable block copolymers for delivery of proteins and water-insoluble drugs. J Control Release 2001 72(l-3) 203-215. 

Ranade, S.V., Richard, R.E., and Hehnus, M.N. Styrenic block copolymers for biomaterial and drug delivery applications, Acta Biomater., 1, 137, 2005. 

Micellar nanocarriers have already been applied successfully for delivery of hydro-phobic drugs [86]. These carriers are usually the product of self-assembled block copolymers, consisting of a hydrophilic block and a hydrophobic block. Generally, an ELP with a transition temperature below body temperature is used as hydrophobic block and the hydrophilic block can be an ELP with a transition temperature above body temperature or another peptide or protein. The EPR effect also directs these types of carriers towards tumor tissue. 

In 2000, the first example of ELP diblock copolymers for reversible stimulus-responsive self-assembly of nanoparticles was reported and their potential use in controlled delivery and release was suggested [87]. Later, these type of diblock copolypeptides were also covalently crossUnked through disulfide bond formation after self-assembly into micellar nanoparticles. In addition, the encapsulation of l-anilinonaphthalene-8-sulfonic acid, a hydrophobic fluorescent dye that fluoresces in hydrophobic enviromnent, was used to investigate the capacity of the micelle for hydrophobic drugs [88]. Fujita et al. replaced the hydrophilic ELP block by a polyaspartic acid chain (D ). They created a set of block copolymers with varying... 

Polymers and copolymers are among the most beneficial materials produced by synthetic chemistry. The invention and commercialization of new polymeric materials with radical new properties provides an opportunity to monopolize the market and justify the expense involved in the research and development. The commercialization of new polymers or copolymers always presents scale-up and design challenges. Scientists have recently developed new polymeric materials whose commercial impact has yet to be realized. Examples are semiconductive and conductive polymers and amphiphilic dendritic block copolymers. Other promising materials, such as polymers for (targeted) drug delivery and... 

---