Block Copolymer Micelles for Drug Delivery

We have briefly reviewed polymer assemblies from block copolymers, their biodistribution, and the targeting technique that guides them to a specific site in the body. In this section, we will describe the practical efforts that have been made in the field of recent DDS using polymer assemblies. 

In order to prepare the micelles using self-assembling amphiphilic block copol3rmers, it is very important to determine the hydrophilic/hydrophobic balance. This is because 

In order to solve these problems and realize a patient-friendly chemotherapy, researchers have developed many intelligent carriers using pol3nneric micelles (13,14). When 

We saw that the matching molecular structures of drugs and polymers are important, and the design of the micelles slightly changes if the drugs are metal complexes. This is 

BLOCK COPOLYMER MICELLES FOR THE DELIVERY OF GENES AND CHARGED MATERIALS 

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Kwon, G., M. Naito, M. Yokoyama, T. Okano, Y. Sakurai, and K. Karaoka. 1997. Block copolymer micelles for drug delivery loading and release of doxorubidnControl. Rel. 48 195-201. 

Kataoka, K., A. Harada, and Y. Nagasaki. 2001. Block copolymer micelles for drug delivery Design, characterization and biological significance. Adv Drug Deliv Rev 47 113. 

K. Kataoka, A. Harada, Y. Nagasaki, Block Copolymer Micelles for Drug Delivery Design, Characterization and Biological Significance , Adv. Drug Deliv. Rev., 47, 113 (2001)... 

Fig.1 Smart block copolymer micelles for drug delivery...

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