Controlled drug delivery block copolymer micelles

Gaucher G, Dufresne MH, Sant VP et al (2005) Block copolymer micelles preparation, characterization and application in drug delivery. J Control Release 109 169-188... 

Kataoka K, Kwon GS, Yokoyama M, Okano T, Sakurai Y. Block-copolymer micelles as vehicles for drug delivery. J Controlled Release 1993 24 119-132. 

Chung, J. E., M. Yokoyama, M. Yamato, T. Aoyagi, Y. Sakurai, and T. Okano. 1999. Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of (sbh propylacrylamide) and poly(butylmethacrylate L Control. Rel62 115-127. 

Gaucher, G., et al. (2005), Block copolymer micelles Preparation, characterization and apphcation in drug delivery, J. Controlled Release, 109(1-3), 169-188. 

Kwon, G. Naito, M. Yokoyama, M. Okano, T. Sakurai, Y. Kataoka, K. Block copolymer micelles for drug delivery loading and release of doxorubicin. J. Controlled Rel. 1997, 48, 195-201. 

Chung J, Yokoyama M, Yamato M, Aoyagi T, Sakurai Y, Okano T. Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly (A-isopropylacrylamide) and poly (butylmethacrylate). Journal of Controlled Release. 1999 62(1) 115-127. 

Yamamoto, Y. et al, 2002. Temperature-related change in the properties relevant to drug delivery of poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles in aqueous milieu. Journal of Controlled Release, 82, 359-371. 

Concerning the application possibilities, block and graft copolymers micelles and their assemblies as PIC are of great practical importance. Of special interest, as outlined in this review, are amphiphilic copolymers with biocompatible and biodegradable sequences, that have obtained growing attention as controlled drug-delivery systems and as potential carriers in gene therapy. 

Zhang, Q., Ko, N.R., Oh, J.K. Recent advances in stimuh-responsive degradable block copolymer micelles synthesis and controlled drug delivery applications. Chem. Conunun. 48(61), 7542-7552 (2012)... 

In 2000, the first example of ELP diblock copolymers for reversible stimulus-responsive self-assembly of nanoparticles was reported and their potential use in controlled delivery and release was suggested [87]. Later, these type of diblock copolypeptides were also covalently crossUnked through disulfide bond formation after self-assembly into micellar nanoparticles. In addition, the encapsulation of l-anilinonaphthalene-8-sulfonic acid, a hydrophobic fluorescent dye that fluoresces in hydrophobic enviromnent, was used to investigate the capacity of the micelle for hydrophobic drugs [88]. Fujita et al. replaced the hydrophilic ELP block by a polyaspartic acid chain (D ). They created a set of block copolymers with varying... 

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