Bladder cancer chemoprevention

Moon RC, KeUoff GJ, Detrisac CJ, Steele VE, Thomas CF, Sigman CC. Chemoprevention of OH-BBN-induced bladder cancer in mice by oltipraz, alone and in combination with 4-HPR and DEMO, Anticancer Res 1994 14 5-11. 

Zhang, Z., Zhang, P., Hamada, M., Takahashi, S., Xing, G., Liu, J., and Sugiura, N. (2008). Potential chemoprevention effect of dietary fucoxanthin on urinary bladder cancer EJ-1 cell line. Oncol. Rep. 20,1099-1103. 

Rao. K.V., Detrisac, C.J., Steele, V.E., Hawk. E.T.. Kelloff, G.J.. and McCormick. DP. (1996) Differential Activity of Aspirin. Ketoprofen and Sulindac as Cancer Chemopreventive Agents in the Mouse Urinary Bladder. Carcinogenesis 17, 1435-1438. 

OGAWA K, HIROSE M, SUGIURA S, CUI L, IMAIDA K, OGISO T and SHIRAI T (2001) Dose-dependent promotion by phenylethyl isothiocyanate, a known chemopreventer, of two-stage rat urinary bladder and liver carcinogenesis , Nutr Cancer, 40 134-9. 

Yang M, Tanaka T, Hirose Y et al (1997) Chemopreventive effects of diosmin and hesperidin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary-bladder carcinogenesis in male ICR mice. Int J Cancer 73 719-724... 

Okajima E, Ozraio S, Endo T, Majima T, Tsutsumi M, Fukuda T, Akai H, Denda A, Hirao Y, Okajima E, Nishino H, Nir Z, Konishi Y (1997) Chemopreventive efficacy of piroxicam administered alone or in combination with lycopene and 6-carotene on the development of rat urinary bladder carcinmna after V-butyl-lV-(4-hydroxybutyl) nitrosamrne treatment. Jpn J Cancer Res 88 543-552... 

The chemopreventive effects of milk thistle have been investigated in various studies. Silybin was found to protect the following organs from chemical- or radiation-induced toxicides rat cardiac muscle cells, kidney cells of rats and monkeys,skin cells of mice, and rat gastric mucosa and pancre-as.3 3 Silymarin was also found to inhibit carcinogenesis in rat colon cells,mice urinary bladder, rat tongue cells, and human breast cancer cells. ... 

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