Biosensing, quantum dots

Sapsford, K.E., Pons, T., Medintz, I.L., and Mattoussi, H. (2006) Biosensing with luminescent semiconductor quantum dots. Sensors 6, 925-953. 

Medintz IL, Clapp AR, Melinger JS, Deschamps JR, Mattoussi H. A reagentless biosensing assembly based on quantum dot donor Forster resonance energy transfer. Adv. Mat. 2005 17 2450-2455. 

H. Peng, L. Zhang, P. A. Kilmartin, Z. Zujovic, C. SoeUer, and J. Travas-Sejdic, Quantum dots and nanostmctured conducting polymers for biosensing apphcations, Int. J. Nanotechn., 6, 418 30 (2009). 

Receptor Protein-Based Bioconjugates of Highly Luminescent CdSe-ZnS Quantum Dots Use in Biosensing Applications... 

Current gold nanopaiticle solution based methods of biosensing are not limited strictly to this one type of nanopaiticle but can incorporate other particles as well. Peptide linked gold nanoparticle - quantum dot biosensors have been created by Chang et al., that rely on the ability of the gold nanoparticles to quench the photoluminescence of the quantum dots when in their close proximity bound state [26]. The method of sensing is also considered an on sensor since the default state of the particles is off (no luminescence), and it is converted to on (luminescence) once sensing takes place. 

Hu X, Han H, Hua L, Sheng Z (2010) Electrogenerated chemiluminescence of blue emitting ZnSe quantum dots and its biosensing for hydrogen peroxide. Biosens Bioelectron 25(7) 1843-1846... 

Eiu X, Cheng E, Eei J, Eiu H, Ju H (2010) Eormation of surface traps on quantum dots by bidentate chelation and their application in low-potential electrochemiluminescent biosensing. Chem Eur J 16(35) 10764-10770. doi 10.1002/chem.201001738... 

Liu X, Ju H (2008) Coreactant enhanced anodic electrocherniluminescence of CdTe quantum dots at low potential for sensitive biosensing amplified by enzymatic cycle. Anal Chem 80(14) 5377-5382. doi 10.1021/ac8003715... 

Mirrors birefiingent PCs (An = 0.366) eleetrical tuning after incorporating liquid crystals (LCs) biosensing internal emitter on incorporation of quantum dots (QDs) into macropores tunability of photonic bandgaps... 

The use of metallic nanoparticles for the electrical contacting of redox enzymes with electrodes, and as catalytic labels for the development of electrochemical biosensors can also be achieved. Similarly, biomolecule-quantum dot hybrid systems may be implemented for optical biosensing, and for monitoring intracellular metabolic processes. Biomaterials and hybrid systems incorporating biomolecules continue to give rise to a variety of different systems better adapted to interface the natural world, which may have a significant role to play in nanoelectronics. 

Jiang, H. Ju, H.X. (2007). Enzyme-quantum dots architecture for highly sensitive electrochemiluminescenece biosensing of oxidase substrates. Chemical Communications, 4,404-406. 

There are a variety of methods to detect the DNA content of food, which can be used to unequivocally identify the nature of the product [4]. Among the various systems for nucleic acid detection, electrochemical DNA analysis can involve direct detection based on a guanine signal (label-free) [5] or an electrocatalytic mechanism (label-based). Quantum dots (QDs) [6,7], metal nanoparticles (NPs) [8,9], enzymes [10,11], and metal complexes [12, 13] can be employed as labels. This chapter focuses on electrochemical biosensing systems based on DNA hybridization events, which offer novel routes for food safety and security applications. Particularly, it describes in detail different approaches reported in the latest years on the immobilization of oligonucleotides on electrochemical transducers for sensing of various compounds with interest in food industry. In addition, some interesting applications in other fields that can easily be extended to that of food are also included. 

Yeh, H. Ho, Y. Wang, T. Quantum dot-mediated biosensing assays for specific nucleic acid detection. Nanomedicine 2005,1,115-121. 

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