Bioreactors mixed batch reactor

Most commercial bioreactions are carried out in batch reactors. The design of a continuous bioreactor is desired since it may prove to be more economically rewarding than batch processes. Most desirable is a reactor that can sustain cells that are suspended in the reactor while growth medium is fed in, without allowing the cells to exit the reactor. Focus mixing modeling, separations, bioprocess kinetics, reactor design. 

Several bioreactor designs are used to produce bioproducts, and include, but are not limited to batch reactors, fed-batch reactors, continuous cultivation reactors, plug flow reactors, recycle bioreactor systems, immobilized cell reactors, biofilm reactors, packed bed reactors, fluidized-bed reactors, and dialysis cultivation reactors (Williams 2002). These reactor types can contain either mixed or pure cultures, and can stimulate heterotrophic and/or phototrophic cellular functions depending on the specific reactor design. Additionally, these reactor schemes can be used to produce products directly, or to harvest biomass or other products for downstream processes. Due to the complex nature of bioreactors, particularly anaerobic digesters, the use of metagenomics is helpful to understand the physiology of such systems. 

Beeause F is the volume processed in time f in a continuous flow bioreactor and Vl is the corresponding volume in a batch reactor, a comparison of Eqs. (11) and (13) shows that batch and plug flow (i.e., packed bed) bioreactors containing the same amount of enzyme will achieve equal conversions in a given time. This is a general conclusion, irrespective of the reaction kinetics. A continues flow packed bed enzyme bioreactor may be advantageous relative to batch reactor, as the unproductive time for batch preparation could be eliminated in the continuous flow unit. However, the batch reactor may have other important advantages such as the ease of pH control in a well-mixed device. 

Batch mixed reactor There are three principal modes of bioreactor operation (a) batch (b) fed batch (c) continuous. 

On the basis of the kinetics of the biocatalysts and the foregoing decisions, the reactor configuration must then be chosen standard or novel Here, availability, experience, desired mixing, and mass-transfer properties play a dominant role. The mode of operation of the bioreactor can be (fed-)batch or continuous. In making this decision, the kinetics, stability and form of the biocatalyst, desired substrate conversion and product concentration, and need for process control all play a role. 

The use of values of p ax for A. latus and R. eutropha and a maximum biomass concentration of 30 gL in Eq. 1 gives a productivity ratio of 8.2 with A. latus and 5.25 with R. eutropha if to is set to a low 10 h. This means that for a fixed desired amount of product per unit of time, the bioreactor volume can be substantially reduced if a continuous culture is chosen over a batch process. From an engineering point of view, the reactor performance would also be easier to control, as lower fermentor volumes lead to less segregation through better mixing at inferior energy expenditure. ... 

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