Biomolecule delivery

Within the context of developing silica nanoparticles as platforms for drug or biomolecule delivery, it will be important to ascertain the required dose of the... 

Miller, T., Goude, M.C., McDevitt, T.C., Temenoff, J.S., 2014. Molecular engineering of gly-cosaminoglycan chemistry for biomolecule delivery. Acta Biomater. 10 (4), 1705-1719. 

Elliott Donaghue, 1., Tam, R., Sefton, M.V., Shoichet, M.S., 2014. Cell and biomolecule delivery for tissue repair and regeneration in the central nervous system. J. Control. Release 190, 219-227. 

Vesicles are of increasing interest for various practical applications, including drug and biomolecule delivery (see Chapter 10.5). 

Wang C, Tong SN, Tse YH, Wang M (2012) Conventional electrospinning vs. emulsion electrospinning a comparative study on the development of nanofibrous drug/biomolecule delivery vehicles. Adv Malta- Res 410 118-121... 

Some of their derivatives have been used as antiviral drugs. Due to their flexible chemistry, they can be exploited to design drug delivery systems and in molecular nanotechnology. In such systems, they can act as a central lipophilic core and different parts like targeting segments, linkers, spacers, or therapeutic agents can be attached to the said central nucleus. Their central core can be functionalized by peptidic and nucleic acid sequences and also by numerous important biomolecules. 

Adsorption of small biomolecules such as amino acids, vitamins, and oligopeptides on mesoporous materials is also an important research target, because it certainly satisfies certain demands in material extraction, drug delivery, and pollutant removal. Vinu and coworkers recently reported systematic research on the adsorption of L-histidine on mesoporous materials [187,188]. Figure 4.22 compares the adsorption... 

To be used as delivery carriers for biomolecules, first it is essential to check whether the conjugates can effectively enter cells. Cellular uptake experiments were performed by using fluorescein isothiocyanate (FITC) conjugated LDH as a probe. Cells (5 x 105/ 1 ml) were incubated with LDH-FITC and its uptake was measured by flow cytometry. As shown in Figure 13.4, the cellular uptake was time and concentration dependent and... 

Fig. 10. Typical chelating agents for radionuclides having the ability for further derivatization with biomolecules for targeted delivery.

These preliminary experimental results illustrate the power of the OFRR to detect specifically biomolecules while using low-cost photonics and simple protocols. The OFRR is a label-free Rl-based sensor, and thus it avoids the extra steps and costly photonics of fluorescence-based techniques. Even compared with other Rl-based techniques, such as SPR, the OFRR is able to use low-cost simple photonics because of its high Q-factor and thus minimal bandwidth requirements. Additionally, the sensor is inherently integrated into the microfluidic sample delivery channel. 

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