Biomolecular surface patterning

The soft elastomeric stamp can be used either as a vehicle for biomolecular surface patterning (an application called microcontact printing (p.CP)) or to create three dimensional reliefs, particularly on polymer materials, as in micromolding in capillaries (MIMIC), microtransfer molding (pTM) or solvent-assisted molding. These techniques have been successfully applied in the fabrication of polymer patterns with dimensions down to the sub-100 nm scale and will be described in this chapter. These patterns have found many relevant applications in the life sciences, where scientists often need to spatially control topographical and chemical properties of surfaces at small scales [1, 5, 6]. 

SCH 13b] ScHROLL P., Fehl C., Dankesreiter S. et al, Photocatalytic surface patterning of cellulose using diazonium salts and visible light . Organic and Biomolecular Chemistry, vol. 11, pp. 6510-6514, 2013. 

J. T. Xu, M. Lynch, S. Nettikadan, C. Mosher, S. Vegasandra, and E. Henderson, Microfabricated "biomolecular ink cartridges"—surface patterning tools (SPTs) for the printing of multiplexed biomolecular arra5 . Sens. Actuator, B, 113,1034-1041 (2006). 

Surface plasmon resonance (SPR) is one of the most sophisticated methods these days for real-time detection and quantification of biomolecular interactions in a nondestructive fashion and without any labeling requirement [148]. SPR is based on the detection of binding pattern changes on a specific sensor surface caused by the interaction between the solute molecules in solution and the immobilized affinity components on the surface. Glass surfaces are coated by a matrix (e.g., dextrin) along with a conductive gold... 

HL/HB patterning can be utilized in applications, including surface-directed capillary flow [7], controlled biomolecular adsorption, microgel synthesis, liquid-assisted molding, liquid-liquid extraction [9], self-alignment, and humidity extraction. 

Hook, A. L., Voelcker, N. H. and Thissen, H. (2009) Patterned and switchable surfaces for biomolecular manipulation , Acta Biomaterialia, 5,2350-2370. 

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