Biomolecular supramolecular complexes

The tremendous progress in supramolecular chemistry and nanoscience provided intellectual concepts and guidelines to implement biomolecules and nano-objects as functional units for the self-assembly of biomolecular structures, or biomolecule-nanoparticle hybrid systems. Such biomolecular supramolecular complexes or hybrid biomolecular composites are anticipated to reveal properties and functions that emerge from the complexity of the structures. 

Nanoparticle and Biomolecular - Nanoparticle Hybrid Supramolecular Complexes for Electrochemical Signaling... 

The data for different types of supramolecular complex were analysed separately (Fig. 9). The distributions of EM values found for complexes based on Fl-bonding, metal coordination and hydrophobic effects are similar to global distribution of EM values for all of the supramolecular complexes (Fig. 8A). Complexes with multiple binding interactions fall in the same range. Flowever, significant differences are observed for the biomolecular... 

Figure 9 Distribution of effective molarity values for different types of supramolecular complex (A) H-bonding, (B) metal coordination, (C) biomolecular complexes, (D) hydro-phobic effects and (E) complexes with multiple binding interactions.

Figure 3 Exclusively enthalpy-driven complexes (a) biotin-streptavidin complex as one of the tightest binding biomolecular systans, achieving an extraordinarily high affinity of 10 M through noncovalent interactions (created by the PyMol software based on PDB entry 2izf) (b) CB[7] complex with l,l -bis(trimethylammoniomethyl)ferrocene as the tightest man-made supramolecular complex that also achieves an extraordinarily high affinity of 10 M through noncovalent interactions.

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