Biomedical modification gene delivery

Layered double hydroxides (LDHs), also known as host-guest layered nanoparticles, were investigated for a variety of biomedical applications, due their ease of synthesis, low cost and good compatibility. The modification of the hydro)yl-rich surface of LDHs with an ATRP initiator was used as a strategy to prepare LDH-based gene delivery vectors, as shown in Scheme 3.26. Surface-initiated ATRP of DMAEMA on a LDH surface... 

Recently, the straightforward synthesis and easy modification of silica nanoparticles has been demonstrated, making them well suitable for biomedical applications such as bioseparation, cell recognition, bacterium and DNA detection, gene delivery, and so on. Silica nanoparticles are biologically inert, have very low toxicity, and are amenable to surface functionalization with a wide variety of molecules and functional groups [108-111]. In Table 7, the synthetic methods for preparation of silica nanoparticles in polymers are shown. 

Abstract Polysaccharides based nanomaterials have diverse applications in biomedical research. This chapter covers one of the major achievements in modification of polysaccharides using microwave irradiation and cationization methods. Additionally chapter focused on mucoadhesive polysaccharides and its recent advancement in nano drug delivery system. Applications such as gene transfection, bone regeneration and vaccine delivery are also separately discussed. 

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