Biomedical composites matrices

Ogomi, D., Serizawa, T. and Akashi, M. (2003) Bioinspired organic-inorganic composite materials prepared by an alternate soaking process as a tissue reconstitution matrix. Journal of Biomedical Materials Research, 67A, 1360-1366. 

Finally, collagen can form a variety of collagen composites with other water-soluble materials. Ions, peptides, proteins, and polysaccharides can all be uniformly incorporated into a collagen matrix. The methods of composite formation include ionic and covalent bonding, entrapment, entanglement, and co-precipitation. A two-phase composite can be formed between collagen, ceramics, and synthetic polymers for specific biomedical applications. 

Applications of polymerization in a supercooled state to the immobilization of various biofunctional components is reviewed. Those applications show advantages because in the low temperature biofunctional components such as proteins, drugs and cells are entrapped or adhered effectively in the polymerized matrix. The immobilized composites are used for biomedical and biochemical systems and processes, such as immuno-diagnosis, artificial organs, drug delivery systems and cell cultures. 

The compositions consist of one or more matrix-forming polymers, such as biomedical PU, biomedical silicones or biodegradable polymers, and antimicrobial agents, especially a synergistic combination of a silver salt and chlorhexidine or its salts. 

W.A. Hanna, RE. Gharib, I.I. Marhoon, Characterization of ceramic filled polymer matrix composite used for biomedical applications, J. Miner. Mater. Character. Eng. 10 (2011) 1167-1178. 

Filament wound flat strip composites of PE fibie-rrinforced ethylene-butane copolymer have been used for diff oit biomedical applications. Composites of three difierent matrix compositions and two winding angles were reported. The matrix composition varied with the copolymer ratio raidering the composite material softening and it is more compliant and suitable for different biomedical application [75]. 

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