Biology factors controlling

Metabolic reactions of toxification are always accompanied by competitive and/or sequential reactions of detoxification that compete with the formation of the toxic metabolite and/or inactivate it. A profusion of biological factors control the relative effectiveness of these competitive and sequential pathways (Section 4). 

The terminal half-life is a hybrid parameter, and its determinants need to be acknowledged. It is either a hybrid PK parameter determined by both clearance and distribution of the substance or, when there is a flip-flop, a PK characteristic of the drug product depending on bioavailability factors (rate and extent of absorption). In this latter case, the terminal half-life does not reflect the intrinsic rate of substance elimination. Whatever the biological factors controlling the terminal half-life, T1/2 should be considered to select an optimal interval between dose administrations. This is clear if one considers a threshold plasma concentration required for AMD efficacy a long terminal half-life will result in a longer time for plasma concentrations to decline to the threshold concentration. 

Clegg, C.H., Linkhart, T.A, Olwin, B.B. and Hauschka, S.D. (1987) Growth factor control of skeletal muscle differentiation occurs in Grphase and is repressed by fibroblast growth factor. Journal of Cell Biology 105, 949-956. 

Bioremediation in situ is much more complicated than the system used in the laboratory controlled condition. Microorganisms in natural community interact with each other and also with other organisms and plants such interactions are more complicated than the scientific technique can delineate simply. Because of this, more systematic approaches are needed to reveal the connectivity between these biological factors and non-biological factors to understand the underlying processes. 

Occupational Hygiene The applied science concerned with die recognition, evaluation and control of chemicals, physical and biological factors arising in or from the workplace which may affect the health or well-being of those at work or in die community. 

Kitano, Y. Chemistry of fossils - Factors controlling the crystal form and the minor element contents of carbonates formed in biological systems. Cherny Chem. Ind. Tokyo 21, 1017 (1968)... 

The third, fourth, and fifth sections investigate the distribution and biological and chemical transformations of reduced sulfur compounds in the oceans. The third section focuses primarily on dimethyl sulfide, which is the predominant form of volatile sulfur in the ocean. Research in the past has concentrated on documenting the distribution of DMS in various oceanic environments. The factors controlling this distribution are not well understood. These chapters examine laboratory and field investigations relating DMS production to productivity and spedation. 

Physicochemical and Biological Factors Influencing Design and Performance of Controlled-Release Formulations... 

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