Biological Data Management

Effective microbial genome data analysis across biological data management systems involves providing support for comparative analysis in an integrated data context. We presented the comparative analysis capabilities provided by the IMG system, in particular those that are based on occurrence profiles. 

Chemoinformatics (or cheminformatics) deals with the storage, retrieval, and analysis of chemical and biological data. Specifically, it involves the development and application of software systems for the management of combinatorial chemical projects, rational design of chemical libraries, and analysis of the obtained chemical and biological data. The major research topics of chemoinformatics involve QSAR and diversity analysis. The researchers should address several important issues. First, chemical structures should be characterized by calculable molecular descriptors that provide quantitative representation of chemical structures. Second, special measures should be developed on the basis of these descriptors in order to quantify structural similarities between pairs of molecules. Finally, adequate computational methods should be established for the efficient sampling of the huge combinatorial structural space of chemical libraries. 

Pervasive computing has numerous applications, but it offers particular potential to the pharmaceutical and health care industries by facilitating the transmission and collection of biological data on a real-time basis outside a clinical setting. That, in turn, means it can be used to monitor patients and manage their health to test new drugs in totally different ways and to deliver health care anywhere, anytime [13]. 

Because of these collection rates, high-throughput synchrotron operations are as much an issue of sample and data management as of data collection. For this reason, SGX-CAT operations were included in the information management systems for the structural biology platform at SGX at the time of beamline commissioning. These data systems directly link beamline operations to SGX efforts in drug discovery and structural proteomics. 

Bioinformatics tools involving computer-based statistical analyses are essential for data management and analysis. When a complex biological sample containing thousands of different proteins is analyzed by multifaceted approaches, such as multidimensional protein identification technology, the identification of the proteins in the mixture is extremely complicated. Even multiple peptide identification methods, such as using both MS and... 

Part of the EMBL, the European Bioinformatics Institute (EBI) is a centre for research and services in bioinformatics. The mission of the EBI is to ensure that information from molecular biology and genome research is placed in the public domain and is accessible freely to all facets of the scientific community. The Institute manages databases of biological data including nucleic acid, protein sequences, and macromolecular structures. 

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