Biological behaviour

The Environmental and Biological Behaviour of Plutonium and Some Other Transuranium Elements" OECD Nuclear Energy Agency Paris, 1981. 

Such models can be used to perform in silico experiments, for example by monitoring the response of a system or its components to a defined intervention. Model output - predictions of biological behaviour - is then validated against in vitro or in vivo data from the real world. 

Biological Behaviour of MYKO 63 in vivo Preclinical Estimation of Eventual Prejudicial Side-Effects... 

Thus bearing this in mind, we were urged to investigate the biological behaviour of MYKO 63 in vivo in order to estimate its side-effects, if any,... 

Biological Behaviour of SOAz in Vivo Preclinical Estimation of Mutagenicity and Teratogenicity... 

The role of fluoride ions will be discussed with regard to their incorporation in mineralised tissues, and the biological behaviour of fluoridated biomaterials will also be reviewed. 

It is in this important family of natural compounds that the first example of the influence of a fluorine atom on biological properties of a molecule has been displayed [130]. This discovery opened the route to very important applications in medicinal field it has been the starting point of the use of fluorination to modify the biological behaviour of a molecule in view of therapeutic applications. 

In spite of these limitations it is possible to obtain valuable data provided specific questions are posed. For example, it has been suggested that the level of methyl-mercury in a sample is a good indicator of the level of mercury toxicity Therefore it will be most useful to detect and quantify this species rather than to use the available resources to detect a wide range of mercury species, whose biological behaviour are yet to be established. It is essential to clearly define the purpose and use to which the information will be put before any speciation experiments are performed. This helps not only in the choice of the appropriate techniques and methods, but also helps to focus attention on the parameters that are useful for the interpretation of the results. 

Top S, Vessieres A, Pigeon P, Rager MN, Huche M, Salomon E, Cabestaing C, Vaissermann J, Jaouen G (2004) Selective estrogen receptor modulators (SERMs) in the cyclopentadienyl rhenium tricarbonyl series. Synthesis and Biological behaviour. Chem-biochem 5 1104—1113... 

The following experiments relate to the chemical and biological behaviour of NADH. Explain what they tell us. 

These properties may account for their biological behaviour. Peroxyacylnitrates — mainly represented by peroxyacetylnitrate, indicated as PAN — originate in the atmosphere over towns and industrial areas, through a mechanism not fully clarified, from olefins, and other hydrocarbons (car exhausts, fuel from car tank evaporation, gas formed in the refineries of crude oil) under photochemical conditions by NOx in the presence of O2 (Stephen, 1969). 

Ru chloride containing Ru and Ru was found to exhibit similar biological behaviour to that of "Tc with two derivatives of HIDA. This suggests that Ru agents may be developed for use in delayed scintigraphic studies of the liver, where "Tc might be unsuitable. 

Most emulsions, unless very dilute, display hoth plastic and pseudoplastic flow behaviour rather than simple Newtonian flow. The flow properties of fluid emulsions should have little influence on their biological behaviour, although the rheological characteristics of semisolid emulsions may affect their performance. The pourability, spreadability and syringeability of an emulsion will, however, be directly determined by its rheological properties. The high viscosity of w/o emulsions leads to problems with intramuscular administration of injectable formulations. Conversion to a multiple emulsion (w/o/w), in which the external oil phase is replaced by an aqueous phase, leads to a dramatic decrease in viscosity and consequent improved ease of injection. 

Recent progress in the fields of NMR spectroscopy and mass spectrometry has allowed stable isotope labelling to become an important technique in metabolic research for determining the biological behaviour of small molecules. Stable isotopomers are more easily prepared and handled than their radioisotopic... 

The biological behaviour of the radiolabelled peptides was evaluated by performing competition, internalization and externahzation studies using AR42J cells, which are known to express somatostatin receptors. Receptor assays were done using membranes obtained from rat brain cortex tissue or from AR42J cells. Biological distribution was evaluated in mice. 

The chemist got confronted with exciting new tasks as to synthesize organic molecules with structures specifically adapted for the binding of metal ions. Natural selection once more proved to be the guiding principle for the elucidation of a scientific problem. The unique biological behaviour now appears to be explainable in terms of physical properties such as complex stability and rates of ligand substitution. 

Pinto-de-Sousa J, David L, Reis GA, et al. Mucins MUCl, MUC2, MUC5AC and MUC6 expression in the evaluation of differentiation and clinico-biological behaviour of gastric carcinoma. Virchows Arch. 2002 440 304-310. 

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