Luminescence bioimaging

Wu J, Ye Z, Wang G, Jin D, Yuan J, Guan Y, Piper J (2009) Visible-light-sensitized highly luminescent europium nanoparticles preparation and application for time-gated luminescence bioimaging. J Mater Chem 19 1258-1264... 

Luminescence Photoluminescence of rare earth oxide nanocrystals is one of their most significant properties of interest for applications. The photoluminescence features of rare earth doped nanomaterials have been reviewed by Liu and Chen in an earlier chapter (Liu and Chen, 2007b). Therefore, we only review some related aspects, such as the major variations in the luminescence features of nanophased rare earth oxides, the application of rare earth doped nanocrystals as multicolor phosphors and as bioimaging probes. 

Bifunctional biolabels with magnetic and luminescent properties are highly desirable for in vitro and in vivo bioimaging. There are several strategies to use NPs to comprise such biolabels, such as core/shell NPs, for example, the magnetic cores of iron oxide doped with cobalt and neodymium and luminescent shells of Gd203 Eu (Dosev et al., 2005,2007). 

Luminescent Rare Earth Complexes as Chemosensors and Bioimaging Probes... 

Because there are many reports concerning TRF measurement in immunoassays [5-9], we focus herein on the use of rare earth complexes as luminescent chemosensors and bioimaging probes. 

Bioimaging Based on Luminescent Rare Earth Complexes... 

An example of the utility of the time-resolved technique in eliminating the interference from background fluorescence in bioimaging is shown in Figure 13.17b. Nagano and coworkers compared time-resolved luminescence microscopy with conventional microscopy using live cultured HeLa cells injected with a Eu + complex Eu-36 (or Eu-37). In the prompt fluorescence images, both the luminescence of Eu-36 (or Eu-37) and weak autofluorescence from... 

Types of Luminescent Rare Earth Complexes for Bioimaging... 

Hybrid Rare Earth Complexes as Luminescent Probes in Bioimaging... 

Rare Earth Luminescent Chemosensors as Bioimaging Probes ofZn ... 

Zinc (Zn +) is the second most abundant metal ion after iron in the human body, and plays critical roles in regulating gene expression, enzyme regulation, and neurotransmission [90]. Zn + is also known to be responsible for the formation of amyloid plaques during the onset of Alzheimer s disease [91], At present, there is considerable interest in the development of Zn +-selective luminescence chemosensors as bioimaging probes [92, 93],... 

Rare Earth Upconversion Luminescence Nanophosphors as Bioimaging Nanoprobes... 

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