Bioelastic matrices

As a test of this perspective, we prepared elastic model proteins with and without cell attachment sequences and cross-linked them to form elastic sheets called bioelastic matrices. Cells do not adhere to these matrices without the cell attachment sequences cells do adhere to the bioelastic matrices containing the cell attachment sequences, as depicted in Figure 2.20. Furthermore, the cells spread out and grew to completely cover the surface. Perhaps even more significantly, cyclic stretching of the... 

I I Bioelastic Matrices Containing Cell Attachment Sequences e.g. X -poly[20(GVGVP),(GRGDSP)]... 

Thus, the potential exists for preparing bioelastic matrices that match the deformable properties of the tissue to be reconstructed, and the potential exists for the matrix to be a temporary functional scaffolding into which the natural cells migrate and attach. There the cells sense the forces that the tissue must sustain and begin reconstructing the appropriate natural tissue. 

Figure 4 Comparison of urotlielial cell growth from human explants onto collagen and bioelastic matrices containing the GRGDSP cell attachment sequence with and without tensional force changes mimicking bladder filling and emptying.

Table 9.8. Pressure ulcer study Subjective observations of skin over the medial malleolus with no bioelastic matrix patch.

These lesions were deeper into the dermis than the superficial abrasions noted when bioelastic matrix patches were present. 

A. Outgrowth from human ureteral explant (dark area) onto static bioelastic matrix, cross-linked poly[40(GVG T),(GRGDSP)J. 

Urry DW, Parker TM, Reid MC, Gowda DC. Biocompatibility of the bioelastic materials, poly (GVGVP) and its gamma-irradiation cross-linked matrix - summary of generic biological test results. J Bioact Compatible Polym 1991 6 263-282. 

D.W. Urry, T.M. Parker, M.C Reid, and D.C. Gowda, Biocompatibility of the Bioelastic Materials, Poly(GVGVP) and Its y-irradiation Cross-linked Matrix Summary of Generic Biological Test Results. J. Bioactive Compatible Pofyw., 6,263-282,1991. 

Accordingly, the design of the appropriate matrix for urological tissue reconstruction should consider the design of a bioelastic material vdth the physical properties of the respective urological tissue. For example, the material for reconstruction of a urological bladder should exhibit the same elastic modulus as the normal bladder and the composition should be able to contain peptide sequences that support cell attachment, growth to confluence and other cellular functions. 

Uny, Dan W., Parker, Timothy M., Reid, Michael C. and Gowda, D. Channe (1991) Biocompatibility- of the bioelastic materials, poly(GVGVP) and its p-irradiation cross-linked matrix Summary of generic biological test results, / Bioactive Compatible Polym., 6, 263-282. 

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