Biodegradable polymers for drug delivery

Kwon GS, Eurgeson DY. Biodegradable polymers for drug delivery systems. Biomed. Polym. 2007 83-110. 

Dossi, M., Storti, G. Moscatelli, D. 2010. Synthesis of poly(alkyl cyanoacrylates) as biodegradable polymers for drug delivery applications. Macromolecular Symposia, 289, 124-128. 

Lu, Y. and S. C. Chen (2004). Micro and nano-fabrication of biodegradable polymers for drug delivery. Advanced Drug Delivery Reviews 56(11) 1621-1633. 

Since the purpose of this book is to describe applications of biodegradable polymers to drug delivery systems, particularly from the perspective of the materials employed, the approach taken in this chapter has been to focus on the natural biodegradable polymers which have been used most extensively as matrices for the delivery of drugs. Consideration was also given to the fact that collagen has not been the subject of any recent reviews. 

Incorporation of the tetrahydrofuran ring into condensation polymers has been accomplished (79USP4180646) by transesterification of orthoester (43) with polyols to prepare poly (orthoesters) (44 Scheme 11). This polymerization reaction has been extended to a wide variety of other orthoester and orthocarbonate starting materials. The product polymers are reported to be excellent biodegradable matrices for drug delivery. 

In addition to these, however, a number of interesting 1,3-dioxane-containing polymers have been obtained (B-77MI11105) from spiroacetals (150) derived from pentaeryth-ritol and functionalized aldehydes (Scheme 47). These and other related spiro-1,3-dioxane polymers have attracted interest as fiber- and film-formers and as biodegradable matrices for drug delivery systems. 

Khan, W., Challa, V.G.S., Langer, R., Domb, A.J., 2014a. Biodegradable polymers for focal delivery systems. In Domb, A.J., Khan, W. (Eds.), Advances in Delivery Science and Technology — Focal Controlled Drug Delivery. Springer Publications, pp. 3—32. 

Garcia-Gonzalez, C.A., Alnaief, M., Smirnova, I., 2011. Polysaccharide-based aerogels— promising biodegradable carriers for drug delivery systems. Carbohydr. Polym. 86 (4), 1425-1438. 

Saito, N., Murakami, N., Takahashi, J., et al. Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins. Adv. Drug Deliv. Rev. 57,1037-1048 (2005)... 

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