Biodegradable polyester scaffolds

Most of the commonly used degradable polymer scaffolds are mechanically strong, but for certain applications such as engineering muscles and tendons, which require considerable elasticity, these polymers are not optimal. Novel biodegradable polyesters have been developed with superior elasticity and strength that resemble vulcanized rubber and are hence termed as biorubber. Scaffolds made with these mechanically functional materials may be useful especially in engineering elastic tissue such as muscular-skeletal tissues and blood vessels. 

Electrospun Scaffolds of Biodegradable Polyesters Manufacturing and Biomedical Application... 

Listed in Table 7.1 are the most commonly used biodegradable polyesters to create electrospun scaffolds for tissue engineering apphcations. The corresponding solvents and concentrations of polymer solutions reported in the literature are also described. 

In general terms, biodegradable polyesters such as PLA, and poly (s-caprolactone) (PCL) are suitable choices for constructing nanofibrous scaffolds," by their good processability and mechanical properties. In fact, electrospun fibres of these polymers could replicate the physical dimensions and morphology of the major components in native ECM. On the other... 

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