Bioconversion of Glycerol into 1,3-Propanediol

pneumoniae grows rapidly on glycerol under aerobic, microaerobic, and anaerobic conditions. 1,3-PD production using different bacteria species is compared in Table 11.1. 

TABLE 11.1 Typical Results of Microbial Production of 1,3-Propanediol Using Different Bacteria Species 

Clostridium diolis DSM15410 PG DSM15410 PG Fed-batch Repeated-batch 

Lactobacillus dioUvorans DSM14421 PG Gic/PG =0.1 mol/mol Gic/PG =0.1 mol/mol, vitamin B12 Batch Fed-batch Fed-batch 

FIGURE 11.1 Metabolic pathway of glycerol conversion by Klebsiella spp. and Clostridium spp. The dotted lines show the pathway by Clostridium spp. 

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Mu XJ, Teng H, Sun YQ, Xiu ZL. (2009). Techno-economic analysis on bioconversion of glycerol into 1,3-propanediol. Chinese J Process Eng, 9, 947-952. 

Zhuge B, Zhang C, Fang HY, Zhuge J, Permaul K. (2010). Expression of 1,3-propanediol oxidoreductase and its isoenzyme in Klebsiella pneumoniae for bioconversion of glycerol into 1,3-propanediol. A/ipZMicrciWci/ Biotechnol, 87, 2177-2184. 

Zhao, L., Zheng, Y, Ma, X., et al., 2009. Effects of over-expression of glycerol dehydrogenase and 1,3-propanediol oxidoreductase on bioconversion of glycerol into 1,3-propandediol by Klebsiella pneumoniae under micro-aerobic conditions. Bioprocess and Biosystems Engineering 32,313-320. 

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