Bioconversion of Glycerol

Mu XJ, Teng H, Sun YQ, Xiu ZL. (2009). Techno-economic analysis on bioconversion of glycerol into 1,3-propanediol. Chinese J Process Eng, 9, 947-952. 

Zhuge B, Zhang C, Fang HY, Zhuge J, Permaul K. (2010). Expression of 1,3-propanediol oxidoreductase and its isoenzyme in Klebsiella pneumoniae for bioconversion of glycerol into 1,3-propanediol. A/ipZMicrciWci/ Biotechnol, 87, 2177-2184. 

Zhao, L., Zheng, Y, Ma, X., et al., 2009. Effects of over-expression of glycerol dehydrogenase and 1,3-propanediol oxidoreductase on bioconversion of glycerol into 1,3-propandediol by Klebsiella pneumoniae under micro-aerobic conditions. Bioprocess and Biosystems Engineering 32,313-320. 

One of the common side effects observed during extractive bioconversion is the accumulation of unwanted by-products in the system which may affect the productivity during continuous operation (14). The build up of glycerol and other non-volatile products was shown to decrease the ethanol yields during repeated fermentations in a two-phase system (12). The problem was, however, solved by dialysing the fermentation broth and also adding more yeast cells. It appears that the combination of ultrafiltration with the phase system may circumvent the problem of by-product inhibition in most of the cases. 

Chen X, Xiu ZL, Wang JF, Zhang DJ, Xu P. (2003a). Stoichiometric analysis and experimental investigation of glycerol bioconversion to 1,3-propanediol by Klebsiella pneumoniae under microaerobic conditions. Enzyme Micmbiol Technol, 33, 386-394. 

Xiu ZL, Zeng AP, An LJ. (2000). Mathematical modehng of kinetics and research on multi-phcity of glycerol bioconversion to 1,3-propanediol. J Dalian Univ Technol, 40, 428-433. 

Ryu, H.W, Kang, K.H., Yun, J.S., 1999. Bioconversion of fumarate to succinate using glycerol as a carbon source. Applied Biochemistry and Biotechnology 77-79, 511-520. 

Saenge, C., Cheirsilp, B., Suksaroge, T.T., Bourtoom, T., 2011a. Potential use of oleaginous red yeast Rhodotorula glutinis for the bioconversion of crude glycerol from biodiesel plant to lipids and carotenoids. Process Biochemistry 46, 210—218. 

Hirschmann, S., Baganz, K., Koschik, I. and Vorlop, K.-D. 2005. Development of an Integrated Bioconversion Process for the Production of 1,3-Propanediol from Raw Glycerol Waters. 

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