Chitosan biocompatibility

Keywords Biocompatibility Chitosan coatings Dental/craniofacial implants Electrodeposition Local controlled drug delivery Orthopedic implants Physical characteristics Silane deposition and bonding... 

W. B. Tan, N. Huang, and Y. Zhang, Ultrafine biocompatible chitosan nanoparticles encapsulating multi-coloured quantum dots for bioapplications, /. Colloid Interface Sci., 310 (2007) 464-470. 

Zhang, H. Mardyani, S. Chan, W.C.W. Kumacheva, E. Design of biocompatible chitosan microgels for targeted pH-mediated intracellular release of cancer therapeutics. Biomacromolecules 2006, 7 (5), 1568-1572. 

Chang SQ, Kang B, Dai YD et al (2011) One-step fabrication of biocompatible chitosan-coated ZnS and ZnS Mn quantum dots via a y-radiation route. Nanoscale Res Lett 6 591-597... 

Li J, Kong M, Cheng XJ, Dang QF, Zhou X, Wei YN, Chen XG. Preparation of biocompatible chitosan grafted poly(lactic acid) nanoparticles. Int J Biol Macromol. 2012 51(3) 221-7. 

Zhou GJ, Wang G, Xu JJ, Chen HY (2002) Reagentless chemiluminescence biosensor for determination of hydrogen peroxide based on the immobilization of horseradish peroxidase on biocompatible chitosan membrane. Sens Actuators B Chem 81(2) 334-339... 

Investigations on biocompatible hydrogels based exclusively on polysaccharide chains were reported chitosan was linked with dialdehyde obtained from scleroglucan by controlled periodate oxidation [218]. The reaction took... 

Another polysaccharide system that has received considerable interest is the chitosans which are water soluble derivatives of chitin. These materials appear to be very biocompatible and degradable and so are potentially excellent candidates as polymeric drug systems (27). 

In view of the conductive and electrocatalytic features of carbon nanotubes (CNTs), AChE and choline oxidases (COx) have been covalently coimmobilized on multiwall carbon nanotubes (MWNTs) for the preparation of an organophosphorus pesticide (OP) biosensor [40, 41], Another OP biosensor has also been constructed by adsorption of AChE on MWNTs modified thick film [8], More recently AChE has been covalently linked with MWNTs doped glutaraldehyde cross-linked chitosan composite film [11], in which biopolymer chitosan provides biocompatible nature to the enzyme and MWNTs improve the conductive nature of chitosan. Even though these enzyme immobilization techniques have been reported in the last three decades, no method can be commonly used for all the enzymes by retaining their complete activity. 

Biodegradable polymers, both synthetic and natural, have gained more attention as carriers because of their biocompatibility and biodegradability and therewith the low impact on the environment. Examples of biodegradable polymers are synthetic polymers, such as polyesters, poly(orfho-esters), polyanhydrides and polyphosphazenes, and natural polymers, like polysaccharides such as chitosan, hyaluronic acid and alginates. 

Richardson, S.C.W., Kolbe, H.V.J., Duncan, R. (1999). Potential of low molecular mass chitosan as a DNA delivery system biocompatibility, body distribution and ability to complex and protect DNA. Int J. Pharm., 178, 231-243. 

Chitosan, the most abundant marine mucopolysaccharide, is derived from chitin by alkaline deacetylation, and possesses versatile biological properties such as biocompatibility, biodegradability, and a non-toxic nature. Due to these characteristics, considerable attention has been given to its industrial applications in the food, pharmaceutical, agricultural, and environmental industries. Currently, chitosan can be considered as a potential marine nutraceutical because its remarkable biological activities have been investigated and reported, in order to exploit its nutraceutical... 

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