Biocompatibility and the Microbiological Features

Facial prostheses may fail due to the limitations in the properties of existing materials, especially the biocompatibility. Biocompatibility of PDMS elastomers (LIM 6050, MDX 4-4210, Silastic 732) was tested in subcutaneous tissue of rats [85]. A histomorphometric evaluation was conducted to analyze the biocompatibihty of the implants. Mesenchymal cells, eosinophils, and foreign-body giant cells were counted. Initially, all implanted materials exhibited an acceptable tissue inflammatory response, with tissue reactions varying from light to moderate. Afterward, a fibrous capsule around the sihcone was observed. In conclusion, the tested silicones were found biocompatible and suitable to use for implantation in both medical and dental areas. Their prosthetic indication is conditioned to their physical properties. Solid sihcone is easier to adapt and does not suffer apparent modifications inside the tissues [85]. 

The surfaces of maxillofacial prostheses made of silicone elastomers exposed to soft tissues may interact with saliva and nasal secretion. These body fluids may lead to colonization of microorganisms on their surfaces leading to their 

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