Biochip applications

Bouaidat S, Berendsen C, Thomsen P et al (2004) Micro patterning of cell and protein nonadhesive plasma polymerized coatings for biochip applications. Lab on a Chip 4(6) 632-637... 

Spatially addressed synthesis is yet another alternative. This does not play an important role in general combinatorial chemistry, but has been used successfully used in biochip applications such as in DNA -probe technology. 

M. Sokuler and L. A. Gheber, Nano fountain pen manufacture of polymer lenses for nano-biochip applications. Nano Lett., 6, 848 (2006),... 

Marquette C.A., Blum L.J., Conducting elastomer surface texturing a path to electrode spotting. Application to the biochip production, Biosens. Bioelectron, 2004, 20 (2) 197-203. 

Optical read out will compete with micro electrode arrays. New developments in array detectors will open new perspectives. Direct optical detection techniques will add new possibilities to bioanalytical applications in addition to fluorescence measurements presently preferred in biochips read out. 

Fluorescent detection technology applicable to biochips is evolving rapidly, resulting in detection instruments that are more powerful, user-friendly, and less expensive. Most systems employ photomultiplier tube (PMT) technology in conjunction with multiple colors, lasers, and a variety of filters. It is essentially a fluorescent microscope that... 

Apparently, biomedical applications are the main demands of the DNA biochip. The selected applications are shown in Table 11.5. 

With this book I hope to address different groups in the scientific community. For beginners in the field a comprehensive overview of the topic is given in ten chapters, including a brief historical review and safety tips. The practitioner will find inspiration for instrumentation as well as examples of applications ranging from photonic crystals to biochips. For experts the book may serve as a quick reference with more than 150 technical tables, diagrams and micrographs, as well as ca. 1000 references cited for easy access to in-depth information. 

Jain, K.K. (2000) Applications of biochip and microarray systems in pharmacogenomics. Pharmacogenomics. 1, 289-307. 

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