BioCatalytics, Inc

BioCatalytics offers one of the broadest ranges of enzymes in the world for carrying out a variety of chemical reactions. In addition, it provides the expertise to guide your synthesis from conception to scale up. 

They also supply a variety of unique chiral fine chemicals, and provide services such as the synthesis of metabolites and other compounds on a custom basis and under confidentiality, as needed. 

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A strategy to access lactones via enzymatic hydrolysis of y- and /3-hydroxy aliphatic nitriles to their corresponding acids with subsequent internal esterification was applied using commercially available enzymes from BioCatalytics Inc. A number of y- and /3-hydroxy aliphatic nitrile substrates (Table 8.11) were evaluated, with the greatest selectivity observed with y-hydroxy nonanitrile, which was converted by nitrilase NIT1003 to the precursor of the rice weevil pheromone in 30% yield, 88% ee with an enatiomeric ratio of = 23 [90],... 

BioCataly- tics BioCatalytics Inc. 39 Congress Street, Suite 303 Pasadena, CA 91105-3022 USA Tel. +1 (626) 229-0588 Fax +1 (626) 535-9465 Email info biocatalytics.com http //www.biocatalytics.com Biocatalytical process development. Experimental enzymes for biocatalysis. Limited production capacity. Distributor for Roche in USA and Canada. 

Nitrilases suitable for the transformations of alicyclic five- and six-membered y-amino nitriles were selected from the set of commercial nitrilases available from BioCatalytics Inc. (now Codexis) [59] and the effects of the substrate structure (ring size, protecting group, and trans versus cis configuration) were studied. N-tosylated derivatives of cis-3-amino cydopentane- and cyclohexanecarboxylic acids were obtained with the highest enantiopurities. Production of N-substituted pyrrolidine-and piperidinecarboxylic acids was also possible using the same nitrilases, but the enantiopurities of these products were generally low [60]. 

T0228 ECO-TEC, Inc., EnviroMech Gold Biocatalytic Contaminant Degradation... 

T0228 ECO-TEC, Inc., EnviroMech Gold Biocatalytic Contaminant Degradation T0231 EFX Systems, Inc., Granular Activated Carbon-Fluidized Bed Reactor (GAC FBR) Process... 

Altus Altus Biologies Inc. 625 Putnam Avenue Cambridge, MA 02139-4807 USA Tel. +1 (617) 299-2900 Fax +1 (617) 299-2999 Email info altus.com http / / www.altus.com Manufacturer of stabilized enzymes for use in industrial, biocatalytical, diagnostic, and medicinal applications. No enzyme production itself. Biocatalytical process development. 

ThermoGen ThermoGen, Inc. 2501 Davey Road Woolridge, IL 60517 USA Tel +1 (630) 783-4600 Fax +1 (630) 783-4909 info thermogen.com http //www.thermogen.com Enzyme discovery. Limited enzyme production capacity. Biocatalytical process development. 

Patel, R. N., Biocatalytic Routes to Chiral Intermediates for Development of Drugs, Biocatalysis for Green Chemistry and Chemical Process Development, John WUey Sons, Inc., Hoboken, NJ, 2011, pp. 89-149. 

T. Fujisawa, M. Shimizu, Biocatalytic approaches to enantiomerically enriched fluoro-organic compounds, in V. A. Soloshonok (Ed.) Enantiocontrolled Synthesis of Fluoro-Organic Compounds Stereochemical Challenges and Biomedical Targets, John Wiley Sons, Inc., Hoboken, 1999, pp. 307-348. 

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