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Biocatalysis selection

In biocatalysis, selectivity is also of great importance. However, in biocatalysis competition often takes place between parallel reactions A —> P and A —> Q (which is also important in homogeneous enantioselective catalysis), or A P and B Q (kinetic resolution, A and B are enantiomers and so are P and Q). With the latter type of competition, the selectivity in a CSTR is reduced as compared to a PFR, just as in the consecutive reactions of the example. On the other hand, for the parallel reactions of A, the selectivity in a CSTR is the same as in a PFR. [Pg.395]

Directed Enzyme Evolution Screening and Selection Methods, Humana Press, Totowa. Vol. 230. (b) Brakmann, S. and Johnsson, K. (eds)(2002) Directed Molecular Evolution of Proteins (or How to Improve Enzymes for Biocatalysis), Wdey-VCH Verlag GmbH, Weinheim. (c) Brakmann, S. and Schwienhorst, A. (eds)... [Pg.57]

Apart from immunoassays, enzyme assays can also be used to detect certain substrates in a clinical diagnostic setting. The benefits of performing enzymatic assays on microchips are the analytical power and minimal reagent use in microfluidic systems combined with the selectivity and amplification factors that come with biocatalysis. [Pg.368]

The electrochemical rate constants for hydrogen peroxide reduction have been found to be dependent on the amount of Prussian blue deposited, confirming that H202 penetrates the films, and the inner layers of the polycrystal take part in the catalysis. For 4-6 nmol cm 2 of Prussian blue the electrochemical rate constant exceeds 0.01cm s-1 [12], which corresponds to the bi-molecular rate constant of kcat = 3 X 103 L mol 1s 1 [114], The rate constant of hydrogen peroxide reduction by ferrocyanide catalyzed by enzyme peroxidase was 2 X 104 L mol 1 s 1 [116]. Thus, the activity of the natural enzyme peroxidase is of a similar order of magnitude as the catalytic activity of our Prussian blue-based electrocatalyst. Due to the high catalytic activity and selectivity, which are comparable with biocatalysis, we were able to denote the specially deposited Prussian blue as an artificial peroxidase [114, 117]. [Pg.443]

One of the most actively investigated aspects of the biohydrolysis of carboxylic acid esters is enantioselectivity (for a definition of the various stereochemical terms used here, see [7], particularly its Sect. 1.5) for two reasons, one practical (preparation of pure enantiomers for various applications) and one fundamental (investigations on the structure and function of hydrolases). The synthetic and preparative aspects of enantioselective biocatalysis by hydrolases have been extensively investigated for biotechnology applications but are of only secondary interest in our context (e.g., [16-18], see Sect. 7.3.5). In contrast, the fundamental aspects of enantioselectivity in particular and of structure-metabolism relationships in general are central to our approach and are illustrated here with a number of selected examples. [Pg.389]

Poppe L, Novak L (1992) Selective biocatalysis. A synthetic approach. VCH, Weinheim Roberts SM, Wiggins K, Casy G (1992) Preparative biotransformations. Whole cell and isolated enzymes in organic synthesis. WUey, Chichester Flohe L (1979) CIBA Foundation Symposium 65 95... [Pg.104]

Biological fuel cells have a long history in the literature,but in recent years, they have come to prominence as more conventional fuel cell technologies have approached mass-market acceptance. Driving the recent ascendance of biofuel cells are the aspects of biocatalysis that are unmatched by conventional low-temperature oxidation—reduction catalysts, namely, activity at near-room temperatures and neutral pH and, more importantly, selective catalytic activity. [Pg.628]

Poppe L, Novak L (1992) Selective biocatalysis a synthetic approach. VCH, Weinheim... [Pg.18]

A major reason why synthetic chemists have become interested in biological methods as mentioned above, is that biocatalysis shows selectivity and specificity in catalysis. This interest in turn is mainly due to the need to synthesise enantiopure compounds as chiral building blocks for dmgs and agrochemicals. [Pg.22]

Faber, K., Ottolina, G. andRiva, S. (1993) Selectivity-Enhancement of Hydrolase Reactions. Biocatalysis, 8, 91-132. [Pg.60]


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See also in sourсe #XX -- [ Pg.169 ]




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Biocatalysis

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